本文選題：鄰苯二甲酸酯類物質代謝產物　切入點：鄰苯二甲酸二(-乙基己基)酯　出處：《衛(wèi)生研究》2017年02期 　論文類型：期刊論文

【摘要】：目的通過尿中鄰苯二甲酸酯類(phthalates)代謝物濃度估計上海市乳母和嬰兒鄰苯二甲酸酯類的暴露水平,并對其累積暴露進行健康風險評估。方法采用橫斷面調查方法,對152對乳母和嬰兒進行問卷調查和一次性隨機尿樣采集。使用液相色譜-串聯(lián)質譜法檢測乳母和嬰兒尿液中的10種鄰苯二甲酸酯類代謝物濃度。使用肌酐校正模型對6種鄰苯二甲酸酯類進行暴露評估。使用危害指數(shù)法進行累積風險評估。結果乳母尿中鄰苯二甲酸酯類代謝產物濃度檢出水平前5位分別為鄰苯二甲酸單異丁酯(mono-isobutyl phthalate,Mi BP)、鄰苯二甲酸單正丁酯(monon-butyl phthalate,Mn BP)、鄰苯二甲酸單乙酯(mono-ethyl phthalate,MEP)、鄰苯二甲酸單甲酯(mono-methyl phthalate,MMP)和鄰苯二甲酸單(2-乙基己基)酯(mono-2-ethylhexyl phthalate,MEHP);嬰兒則分別為Mi BP、Mn BP、MEP、MEHP和單(2-乙基-5-羧基戊基)鄰苯二甲酸酯(mono-2-ethyl-5-carboxypentyl phthalate,MECPP)。以尿中鄰苯二甲酸酯類代謝產物來估算鄰苯二甲酸酯類的每日暴露量(estimated daily intake,EDI),鄰苯二甲酸二(2-乙基己基)酯(di-2-ethylhexyl phthalate,DEHP)在乳母和嬰兒中均濃度最高,幾何均值分別達到6.64和14.02μg/(kg·d),其他鄰苯二甲酸酯類在乳母和嬰兒中的EDI值從高到低鄰苯二甲酸二異丁酯(di-i-sobutyl phthalate,Di BP)和鄰苯二甲酸二正丁酯(di-n-butyl phthalate,Dn BP)、鄰苯二甲酸二乙酯(diethyl phthalate,DEP)、鄰苯二甲酸二甲酯(di-methyl phthalate,DMP)和鄰苯二甲酸丁基芐酯(butyl-benzyl phthalate,BBP)。采用危害指數(shù)法(hazard index,HI)評估累積暴露風險,乳母HI≥1的比例約為5.92%,嬰兒HI≥1的比例約為32.24%。結論上海市乳母和嬰兒接觸鄰苯二甲酸酯類存在一定的健康風險,嬰兒的風險高于乳母。
[Abstract]:Objective to estimate the exposure levels of phthalates in the urine of lactating mothers and infants in Shanghai and to assess the health risk of their cumulative exposures. A questionnaire survey was conducted in 152 nursing mothers and infants and a single random urine sample was collected. The concentrations of 10 phthalate metabolites in the urine of lactating mothers and infants were determined by liquid chromatography-tandem mass spectrometry. Creatinine calibration model was used. The cumulative risk was assessed by hazard index method. Results the first five levels of phthalate metabolites in the urine of lactating mother were found to be monomethyl phthalate. Mono-isobutyl phthalate (Mi BPN), monon-butyl phthalate (n-butyl phthalate), mono-ethyl phthalate (MBP), mono-ethyl phthalate (MEPN), mono-methyl phthalate (MMPP) and mono-2-ethylhexyl phthalyl phthalyl phthalate (MEHPN) in infants; and in infants, Mi BPg-Mn BP- MEPMEPMEHP and mono-2-ethylhexyl phthalate (MEHPHPU), respectively, and mono-methyl phthalate mono-methyl phthalate (MMPP) and mono-2-ethylhexyl phthalyl phthalyl phthalate (MEHPN); in infants, the mono-2-ethylhexyl phthalate mono-2-ethylhexyl phthalate (M2-ethylhexyl) phthalate is mono-2-ethylhexyl phthalate; Pentyl) phthalate mono-2-ethyl-5-carboxypentyl phthalate phthalate (MECPPN). The daily exposure of phthalates to phthalates was estimated by the metabolites of phthalates in urine. The concentrations of di-2-ethylhexyl phthalate di-2-ethylhexyl phthalate (DEHP) were the highest in both mother and infant. The geometric mean values were 6.64 and 14.02 渭 g / kg 路dl, respectively. The EDI values of other phthalates in nursing mothers and infants ranged from high to low, and di-i-sobutyl phthalate Di BPs, di-n-butyl phthalate di-n-butyl phthalateDn BP-, diethyl phthalate diethyl phthalate, diethyl phthalate, diethyl phthalate, diethyl phthalate, diethyl phthalate, dibutyl phthalate, dibutyl phthalate, diethyl phthalate, diethyl phthalate, diethyl phthalate, dibutyl phthalate, Dimethyl phthalate (DMP) and Ding Ji benzyl phthalate phthalate (BBP) were used to assess the cumulative exposure risk. The ratio of HI 鈮，

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