本文關鍵詞： 藥物粉塵 危害分級 產塵點 工藝改造 氣流組織 除塵裝置 個體防護　出處：《河北科技大學》2012年碩士論文　論文類型：學位論文

【摘要】：7-氨基頭孢烷酸（簡稱7-ACA）是頭孢菌素關鍵性中間體，具有強致敏性，且對作業(yè)人員及環(huán)境的影響非常嚴重。石藥集團中潤制藥有限公司7-ACA的產量在全國排名第一，企業(yè)的清潔及安全生產對我國頭孢類藥物的健康發(fā)展起到了舉足輕重的作用。本課題結合企業(yè)生產車間粉塵現狀，對7-ACA藥物粉塵防治對策進行研究，制定有針對性的防治技術方案，為石藥集團中潤制藥有限公司車間7-ACA粉塵綜合治理工程的實施提供必要的理論及技術支持。 對比研究了國內外針對藥物粉塵控制的危害分級分類，明確了對該類粉塵進行管理的依據。結合7-ACA生產工藝，辨識關鍵產塵點及產塵原因，，查找產塵原因及現有粉塵防治對策的缺陷。進行工藝設備改造，將干燥、過篩、分裝設備及粉體輸送生產工藝過程密閉化，從源頭上解決了生產過程中藥塵的產生。進行通風系統(tǒng)及除塵裝置改造，優(yōu)化了氣流組織，車間內采用側送下側回的通風方式，將原有袋式除塵器改為濾筒式除塵器。加強個體防護，確定高致敏性粉塵崗位呼吸防護用品配備標準，采用高過濾效率的濾棉，使在正常工作環(huán)境中實際接觸的高致敏性粉塵濃度低于0.001mg/m~3。 課題研究對中潤公司7-ACA藥物粉塵防治工作具有重要的指導意義，也為同行業(yè)及類似企業(yè)的進行強致敏性藥物粉塵的防治提供了技術參考及借鑒。
[Abstract]:7-Aminocefosporinic acid (7-ACAA) is a key intermediate of cephalosporin, which is highly sensitive and has a very serious impact on workers and environment. The output of 7-ACA in Zhongrun Pharmaceutical Co., Ltd., Shiyao Group, ranks first in China. The clean and safe production of enterprises has played an important role in the healthy development of cephalosporins in China. In order to provide necessary theoretical and technical support for the implementation of 7-ACA comprehensive dust control project in the workshop of Zhongrun Pharmaceutical Co., Ltd. In this paper, the classification and classification of the hazards of drug dust control at home and abroad are comparatively studied, and the basis for the management of this kind of dust is clarified. Combined with the 7-ACA production process, the key dust producing points and the causes of dust production are identified. To find out the causes of dust production and the defects of existing measures for dust prevention and control. The process equipment was reformed and the drying, sifting, packing equipment and powder conveying process were sealed. The production of traditional Chinese medicine dust was solved from the source. The ventilation system and dust removal device were reformed, the airflow organization was optimized, and the ventilation mode was adopted in the workshop. Change the original bag dust collector into a filter tube type dust collector. Strengthen individual protection, determine the standard of respiratory protection equipment for high sensitive dust post, and adopt filter cotton with high filtration efficiency. The concentration of highly sensitive dust actually exposed in normal working environment is less than 0. 001 mg / m ~ (3). The research is of great significance to the prevention and control of 7-ACA drug dust in Zhongrun Company, and it also provides a technical reference for the prevention and treatment of highly sensitive drug dust in the same industry and similar enterprises.
【學位授予單位】：河北科技大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R135

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