【摘要】：目的:制備阿苯達(dá)唑納米脂質(zhì)體凍干粉并對(duì)其性質(zhì)進(jìn)行考察。方法:利用冷凍干燥法制備阿苯達(dá)唑納米脂質(zhì)體凍干粉,以粒徑、包封率聯(lián)合外觀、再分散性為指標(biāo),采用單因素試驗(yàn)聯(lián)合正交試驗(yàn)篩選凍干處方工藝�？疾靸龈汕啊⒑笾|(zhì)體的形態(tài)學(xué)變化、粒徑、Zeta電位、水分含量、4℃下12個(gè)月的穩(wěn)定性。結(jié)果:采用外加凍干保護(hù)劑的總量為10%,其中葡萄糖-海藻糖-甘露醇配比為1.0∶1.0∶3.0,以速凍的方式,于-35℃冰箱預(yù)凍18 h,冷凍干燥48 h獲得凍干粉。與凍干前比較,凍干后脂質(zhì)體形態(tài)未發(fā)生明顯變化,可見(jiàn)清晰的磷脂雙分子層膜結(jié)構(gòu);凍干前、后脂質(zhì)體的粒徑分別為(208.63±1.04)、(223.04±2.02)nm,Zeta電位分別為(-15.6±0.04)、(-19.4±0.06)m V,包封率分別為(94.62±0.49)%、(91.10±0.46)%(n=3);與脂質(zhì)體比較,脂質(zhì)體凍干粉在4℃下12個(gè)月較穩(wěn)定。結(jié)論:成功制得阿苯達(dá)唑納米脂質(zhì)體凍干粉,其穩(wěn)定性優(yōu)于阿苯達(dá)唑納米脂質(zhì)體,凍干工藝可行。
[Abstract]:Objective: to prepare albendazole nano-liposomes freeze-dried powder and investigate its properties. Methods: albendazole nano-liposomes freeze-dried powder was prepared by freeze-drying method. The freeze-drying prescription process was screened by single factor test combined with orthogonal test, taking the combined appearance of particle size, entrapment efficiency and redispersion as the index. The morphological changes, particle size, Zeta potential and water content of liposomes before and after freeze-drying were investigated, and the stability of liposomes at 4 鈩，

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