【摘要】：目的探討環(huán)氧化酶1(COX-1)(A842G、C50T)、P2Y1(A1622G、C893T)、GPⅠa(C807T、G873A)及GPⅢa(T1565C)4個(gè)基因中7個(gè)位點(diǎn)的多態(tài)性與阿司匹林(ASP)抵抗(AR)的相關(guān)性。方法選取2011年10月—2013年12月武警浙江省總隊(duì)杭州醫(yī)院內(nèi)科住院的動(dòng)脈粥樣硬化患者243例,測(cè)定患者血小板聚集(PA)率,并將患者分為AR組,ASP半抵抗(ASR)組,ASP敏感(AS)組。測(cè)定各組COX-1、P2Y1、GPⅠa及GPⅢa基因型。比較3組患者一般資料及COX-1、P2Y1、GPⅠa、GPⅢa基因多態(tài)性。結(jié)果 AR組28例,ASR組71例,AS組144例。3組患者的年齡、性別、吸煙率、高血壓發(fā)生率、總膽固醇、三酰甘油和低密度脂蛋白水平比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。3組患者糖尿病發(fā)生率比較,差異有統(tǒng)計(jì)學(xué)意義(P0.01);AS組患者糖尿病發(fā)生率低于AR組(P0.05)。3組間COX-1(842 AG)、COX-1(50 CT)、P2Y1(1622 AG)、GPⅠa(873 GA)、GPⅢa(1565 TC)頻率比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。3組間P2Y1(893 CT)和GPⅠa(807 CT)頻率比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05);AR組和ASR組P2Y1(893 CT)、GPⅠa(807 CT)頻率高于AS組(P0.01)。結(jié)論 P2Y1(C893T)、GPⅠa(C807T)等位基因的變異與AR具有一定程度的關(guān)聯(lián),為指導(dǎo)臨床用藥提供了參考依據(jù)。
[Abstract]:Aim to investigate the association of seven polymorphisms of cyclooxygenase 1 (COX-1) (A842G, C50T), P2Y1 (A1622G, C893T), GPIa (C807T, G873A) and GPIIa (T1565C) genes with aspirin (ASP) resistance to (AR). Methods from October 2011 to December 2013, 243 patients with atherosclerosis were selected from the Department of Medicine of Hangzhou Hospital of the Armed Police Force in Zhejiang Province. The platelet aggregation (PA) rate of the patients was measured and divided into AR group and ASP semi-resistant (ASR) group, and the patients were divided into AR group and ASP semi-resistant (ASR) group. ASP sensitive (AS) group. The genotypes of COX-1,P2Y1,GP 鈪，

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