【摘要】：為了研究駐極體環(huán)保菌素A貼劑的透皮給藥機(jī)制,利用藥劑學(xué)技術(shù)制備了環(huán)孢菌素A貼劑,通過(guò)柵控恒壓電暈充電系統(tǒng)將聚丙烯(PP)薄膜制備成初始表面電位為500 V和1 000 V的駐極體,并將環(huán)孢菌素A貼劑與駐極體復(fù)合后得到了駐極體環(huán)孢菌素A貼劑。借助于開路熱刺激放電(TSD)技術(shù)研究了不同初始表面電位的駐極體對(duì)環(huán)孢菌素A貼劑的熱釋電特性。結(jié)果顯示:1環(huán)孢菌素A貼劑中基質(zhì)和模型藥物分子處于弱極性和非極性狀態(tài),其開路TSD電流譜中出現(xiàn)相應(yīng)的弱小低溫偶極峰群、高溫偶極峰群和空間電荷峰;2不同初始表面電位的正極性駐極體能提供穩(wěn)定的外靜電場(chǎng)以作用于環(huán)孢菌素A貼劑,500 V駐極體作用時(shí)間為10 h時(shí),環(huán)孢菌素A貼劑的40~60℃低溫偶極電流峰遷移至40~70℃溫區(qū),且峰形展寬和峰值相應(yīng)增加;3隨著駐極體作用時(shí)間的延長(zhǎng)和作用電壓的增加,駐極體外電場(chǎng)能使更多的環(huán)孢菌素A貼劑內(nèi)極化分子分子極化程度增加并沿外電場(chǎng)方向排列取向。可得結(jié)論:駐極體可引起環(huán)孢菌素A的極化,環(huán)孢菌素A的極化程度隨駐極體外靜電場(chǎng)及作用時(shí)間的增加而加強(qiáng),駐極體可實(shí)現(xiàn)對(duì)環(huán)孢菌素A貼劑中的模型藥物的可控釋放。
[Abstract]:In order to study the transdermal delivery mechanism of electret environmental protection bacteriocin A patch, cyclosporin A patch was prepared by pharmaceutical technique. An electret with initial surface potential of 500V and 1 000V was prepared from polypropylene (PP) film by gate controlled constant voltage corona charging system. The electret cyclosporin A patch was obtained by combining cyclosporin A patch with electret. The pyroelectric properties of different initial surface potential electrets for cyclosporin A patch were studied by open-circuit thermal stimulation discharge (TSD) technique. The results showed that the matrix and model drug molecules were in weak polar and nonpolar states, and the corresponding weak low temperature dipole peaks appeared in the open circuit TSD current spectrum. The positive electrets with different initial surface potentials of high temperature dipole group and space charge peak can provide a stable external electrostatic field to act on the 500V electret with cyclosporin A patch for 10 h. The low temperature dipole current peak of cyclosporin A patch moves to the temperature range of 40 ~ 70 鈩，

本文編號(hào)：2238325