噬菌體與抗菌劑聯(lián)合應用研究進展
發(fā)布時間:2018-08-23 20:09
【摘要】:目前,細菌耐藥性已成為危害公眾健康的嚴重問題。噬菌體是地球上存在最豐富的生物,其作為細菌病毒具有裂解細菌的作用,許多動物模型試驗及臨床測試已經(jīng)證明裂解性噬菌體有殺菌功效,噬菌體療法的應用逐漸成為研究的必然選擇。噬菌體雖然有希望成為抗生素替代品,但是越來越多的研究表明噬菌體與抗菌劑組合比二者單一使用能更有效地控制病原菌。本文就噬菌體與抗菌劑聯(lián)合應用進行綜述,主要討論了噬菌體與抗生素、精油和細菌素等抗菌劑聯(lián)合應用的研究進展。
[Abstract]:At present, bacterial resistance has become a serious problem that endangers public health. Bacteriophage is one of the most abundant organisms on earth. As a bacterial virus, bacteriophage has been proved to be bactericidal by many animal model tests and clinical tests. The application of bacteriophage therapy has gradually become the inevitable choice of research. Although bacteriophage is promising as a substitute for antibiotics, more and more studies have shown that the combination of bacteriophage and antimicrobial agents can control pathogens more effectively than the single use of the bacteriophages and antimicrobial agents. In this paper, the application of bacteriophage and antimicrobial agents was reviewed, and the research progress of the combination of bacteriophage and antibiotics, essential oil and bacteriocin was discussed.
【作者單位】: 大連理工大學生命科學與技術學院;動物性食品安全保障技術教育部工程研究中心;
【基金】:國家海洋公益項目(No.201405003-3)
【分類號】:R978
本文編號:2199791
[Abstract]:At present, bacterial resistance has become a serious problem that endangers public health. Bacteriophage is one of the most abundant organisms on earth. As a bacterial virus, bacteriophage has been proved to be bactericidal by many animal model tests and clinical tests. The application of bacteriophage therapy has gradually become the inevitable choice of research. Although bacteriophage is promising as a substitute for antibiotics, more and more studies have shown that the combination of bacteriophage and antimicrobial agents can control pathogens more effectively than the single use of the bacteriophages and antimicrobial agents. In this paper, the application of bacteriophage and antimicrobial agents was reviewed, and the research progress of the combination of bacteriophage and antibiotics, essential oil and bacteriocin was discussed.
【作者單位】: 大連理工大學生命科學與技術學院;動物性食品安全保障技術教育部工程研究中心;
【基金】:國家海洋公益項目(No.201405003-3)
【分類號】:R978
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