本文選題：用藥頻度 + 病原菌��； 參考：《中華醫(yī)院感染學(xué)雜志》2015年01期

【摘要】：目的根據(jù)臨床分離的主要病原菌的耐藥性,結(jié)合抗菌藥物的臨床應(yīng)用進(jìn)行分析,為臨床合理用藥提供參考。方法對(duì)醫(yī)院2012年3月-2013年7月臨床分離的主要病原菌的耐藥性及同期抗菌藥物的用藥頻度進(jìn)行統(tǒng)計(jì)分析,采用WHO推薦的限定日劑量(DDD)值分析法。結(jié)果 2012年3月-2013年7月醫(yī)院抗菌藥物使用DDDs排序前3位的依次為頭孢呋辛、左氧氟沙星和奧硝唑,頭孢類抗菌藥物仍為臨床首選藥物;共分離出病原菌1 196株,其中革蘭陰性菌599株占50.1%,革蘭陽(yáng)性菌365株占30.5%,真菌232株占19.4%;革蘭陰性菌中的大腸埃希菌和肺炎克雷伯菌對(duì)亞胺培南敏感,耐藥率為0,其次對(duì)哌拉西林/他唑巴坦、頭孢哌酮/他唑巴坦和阿米卡星有較好的敏感性,耐藥率17.3%;主要革蘭陽(yáng)性菌對(duì)萬古霉素和替考拉寧敏感率為100.0%,對(duì)青霉素類和頭孢類耐藥性嚴(yán)重。結(jié)論常見病原菌以革蘭陰性菌為主,對(duì)多種抗菌藥物的耐藥率較高,頭孢類抗菌藥物是臨床使用頻度最高的藥物,應(yīng)加強(qiáng)對(duì)抗菌藥物的耐藥性監(jiān)測(cè),合理使用抗菌藥物。
[Abstract]:Objective to analyze the drug resistance of the main pathogenic bacteria and the clinical application of antimicrobial agents in order to provide reference for rational use of antibiotics. Methods from March 2012 to July 2013, the drug resistance of the main pathogenic bacteria and the frequency of antibiotics used in the same period were statistically analyzed. The DDD value recommended by WHO was used to analyze the drug resistance of the main pathogenic bacteria. Results from March 2012 to July 2013, the first three antibiotics in the order of DDDs were cefuroxime, levofloxacin and ornidazole, and cephalosporins were still the first choice in clinic, and 1 196 strains of pathogenic bacteria were isolated. Among them, 599 strains of Gram-negative bacteria accounted for 50.1%, 365 strains of Gram-positive bacteria accounted for 30.5% and 232 strains of fungi accounted for 19.4.The Escherichia coli and Klebsiella pneumoniae were sensitive to imipenem and resistant to imipenem, followed by piperacillin / tazobactam. Cefoperazone / tazobactam and amikacin showed good sensitivity with drug resistance rate of 17.3.The sensitivity of the main gram-positive bacteria to vancomycin and teicoplanin was 100.0 and the drug resistance to penicillin and cephalosporins was serious. Conclusion Gram-negative bacteria are the most common pathogens, and the resistance rate to many kinds of antibiotics is high. Cephalosporins are the most frequently used drugs in clinical use. It is necessary to strengthen the monitoring of antimicrobial resistance and rational use of antimicrobial agents.
【作者單位】： 襄陽(yáng)市中心醫(yī)院藥劑科;襄陽(yáng)市中心醫(yī)院檢驗(yàn)科;首都醫(yī)科大學(xué)中醫(yī)藥學(xué)院;
【基金】：北京教委專項(xiàng)基金資助項(xiàng)目(12ZYH03)
【分類號(hào)】：R95

【共引文獻(xiàn)】

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本文編號(hào)：2095997