本文選題：泮托拉唑鈉 + 熒光猝滅�。� 參考：《華南師范大學(xué)學(xué)報(bào)(自然科學(xué)版)》2017年01期

【摘要】：在優(yōu)化的實(shí)驗(yàn)條件下,運(yùn)用熒光光譜法和紫外光譜法研究牛血清白蛋白(BSA)與泮托拉唑鈉(PS)的結(jié)合作用.研究表明:PS對BSA的熒光有猝滅作用,屬于靜態(tài)猝滅.BSA能運(yùn)載PS,是一個(gè)自發(fā)過程,其作用力類型主要為氫鍵和范德華力.BSA的亞螺旋域ⅢA是主要結(jié)合位置,離酪氨酸殘基更近,有正協(xié)同作用.PS對BSA構(gòu)象產(chǎn)生影響,使BSA腔內(nèi)疏水環(huán)境的極性減弱.該研究對揭示藥物動力學(xué)問題及后續(xù)抗菌類藥物的研發(fā)提供了理論依據(jù).
[Abstract]:The interaction of bovine serum albumin (BSA) with pam Tora sodium (PS) was studied by fluorescence and UV spectra under optimized experimental conditions. The results show that the fluorescence of BSA is quenched by: PS, which belongs to static quenching. BSA can transport PS. it is a spontaneous process. The force type is mainly hydrogen bond and van der Waals force. BSA subhelical domain 鈪，

本文編號：2095934