本文選題：光動力學療法　切入點：光敏劑　出處：《藥學學報》2015年08期

【摘要】：光動力學療法(photodynamic therapy,PDT)具有良好的靶向性、微創(chuàng)性和安全性,已成為腫瘤防治中的重要領(lǐng)域,而光敏劑(photosensitizer)則是PDT的核心和關(guān)鍵。本文報道了一種用于卟啉類光敏劑的新HPLC分析方法,采用Shiseido Capcell PAK C18(150 mm×4.6 mm,5μm)色譜柱,柱溫30℃,甲醇-1%冰乙酸溶液為流動相,流速1.0 m L·min-1,梯度洗脫,檢測波長380 nm。方法學研究表明本方法具有良好的專屬性、精密度、準確度和重復(fù)性,適用于卟啉類光敏劑的純度檢查和含量測定,已在新型光敏劑華卟啉鈉的開發(fā)中發(fā)揮了重要導(dǎo)向作用。
[Abstract]:Photodynamic therapy (PDT) has become an important field in the prevention and treatment of tumor because of its good targeting, minimally invasive and safety, and Guang Min photosensitizer is the core and key of PDT.A new HPLC analysis method for porphyrin Guang Min was reported in this paper. The column was Shiseido Capcell PAK C18150 mm 脳 4.6 mm ~ 5 渭 m, column temperature was 30 鈩，

本文編號：1715265