本文選題：基因多態(tài)性　切入點(diǎn)：麥考酚酸　出處：《中國(guó)醫(yī)院藥學(xué)雜志》2015年03期 　論文類型：期刊論文

【摘要】：目的:綜述近年來(lái)國(guó)內(nèi)外學(xué)者對(duì)基因多態(tài)性與麥考酚酸(MPA)及其代謝產(chǎn)物藥動(dòng)學(xué)關(guān)系的研究,為指導(dǎo)臨床合理用藥提供循證依據(jù)。方法:查閱國(guó)內(nèi)外相關(guān)文獻(xiàn),進(jìn)行系統(tǒng)的文獻(xiàn)整理和綜合分析。結(jié)果:各研究間由于研究對(duì)象的病理生理差異、種族差異、突變頻率不同、合并用藥的影響等,研究結(jié)果存在差異。其中,可能與MPA及其代謝產(chǎn)物藥動(dòng)學(xué)有關(guān)的位點(diǎn)有:UGT2B7 C802T、SLCO1B3 T334G、UGT1A9 T-275A/或C-2152T;存在爭(zhēng)議的位點(diǎn)有:UGT1A8*2、UGT1A9 I399C/T、UGT1A9 C-440T、ABCC2 C-24T、ABCG2 C421A;可能無(wú)關(guān)的位點(diǎn)有:CES2、SLCO1B1、SLCO2B1、ABCB1 C3435T。結(jié)論:基因多態(tài)性可以影響MPA及其代謝產(chǎn)物的藥動(dòng)學(xué),要進(jìn)一步闡明基因多態(tài)性與MPA及其代謝產(chǎn)物藥動(dòng)學(xué)的關(guān)系,尚需更多高質(zhì)量、大樣本的體內(nèi)研究。
[Abstract]:Objective: to review the recent studies on the relationship between gene polymorphism and mycophenolic acid (MPA) and its metabolite pharmacokinetics, and to provide evidence-based evidence for guiding rational drug use in clinical practice. Methods: the relevant literature at home and abroad was reviewed. A systematic literature review and comprehensive analysis were carried out. Results: there were differences in the results of the studies due to the pathophysiological differences, ethnic differences, mutation frequencies and the effects of combined use of drugs. The possible sites associated with MPA and its metabolites pharmacokinetic are: UGT2B7 C802TnSLCO1B3 T334GUGT1A9 T-275A9 or C-2152T; disputed loci UGT1A8A9 I399C / TUGT1A9 C-440TABCC2 C-24TnABCG2C421A; perhaps unrelated loci: CES2SLCO1B1B1ABB1ABCB1SLC3435T.Conclusion: genetic polymorphisms may affect the pharmacokinetics of MPA and its metabolites. In order to further elucidate the relationship between gene polymorphism and pharmacokinetics of MPA and its metabolites, more high quality and large sample in vivo studies are needed.
【作者單位】： 南京軍區(qū)福州總醫(yī)院藥學(xué)科;沈陽(yáng)藥科大學(xué)藥學(xué)院;
【分類號(hào)】：R969

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本文編號(hào)：1620810