本文選題：艾瑞昔布　切入點(diǎn)：甲苯磺丁脲　出處：《中國(guó)醫(yī)藥工業(yè)雜志》2015年02期 　論文類型：期刊論文

【摘要】：利用探針?biāo)幬锓ㄑ芯堪鹞舨紝?duì)大鼠體內(nèi)CYP2C9酶的影響。將大鼠隨機(jī)分為試驗(yàn)組和對(duì)照組,每組18只,試驗(yàn)組經(jīng)口灌胃艾瑞昔布,對(duì)照組經(jīng)口灌胃等量蒸餾水,連續(xù)給藥7 d(2次/d)。d8,每只大鼠經(jīng)口灌胃甲苯磺丁脲,并于給藥后24 h內(nèi)眼內(nèi)眥取血,以HPLC法測(cè)定血漿藥物濃度,擬合藥動(dòng)學(xué)參數(shù),并對(duì)兩組的藥動(dòng)學(xué)參數(shù)進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果表明,試驗(yàn)組的AUC0→24 h、AUC0→∞、tmax、CL和V與對(duì)照組相比均有顯著性差異(P0.05)。合用艾瑞昔布后,甲苯磺丁脲的AUC0→24 h和AUC0→∞顯著降低,CL明顯增加,表明艾瑞昔布誘導(dǎo)CYP2C9酶的活性,加快甲苯磺丁脲的代謝。
[Abstract]:The effects of alexib on CYP2C9 enzyme in rats were studied by probe drug method. The rats were randomly divided into two groups: the experimental group and the control group, 18 rats in each group. The experimental group was treated by oral administration of eroxib, and the control group was given the same amount of distilled water by oral administration. After 7 days of administration, each rat was given intragastric administration of tolbutylurea, and blood was collected from the medial canthus within 24 hours after administration. Plasma drug concentration was measured by HPLC method, and the pharmacokinetic parameters were fitted. The pharmacokinetic parameters of the two groups were statistically analyzed. The results showed that the AUC0 of the experimental group was higher than that of the control group. 鈫，

本文編號(hào)：1611466