本文選題：富馬酸二甲酯　切入點：有關(guān)物質(zhì)　出處：《沈陽藥科大學學報》2015年11期 　論文類型：期刊論文

【摘要】：目的建立高效液相色譜法測定富馬酸二甲酯原料藥中有關(guān)物質(zhì)的方法。方法采用Thermo C18色譜柱,以乙腈-體積分數(shù)為0.05%的磷酸溶液(體積比為10∶90)為流動相,流速:1 m L·min-1,檢測波長:211 nm,進樣量:20μL,柱溫:35℃。結(jié)果雜質(zhì)A、B、C、D和富馬酸二甲酯的定量限分別為0.009、0.036、0.014、0.073和0.020 mg·L-1,雜質(zhì)A、B、C、D和富馬酸二甲酯的線性分別為0.160~1.602、0.160~1.599、0.160~1.602、0.160~1.600和0.160~1.601 mg·L-1,雜質(zhì)A、B、C、D的平均回收率分別為98.5%、98.5%、100.0%和98.6%。結(jié)論本法可作為富馬酸二甲酯有關(guān)物質(zhì)的測定方法。
[Abstract]:Objective to establish a high performance liquid chromatographic method for the determination of related substances in dimethyl fumarate raw materials. Methods Thermo C18 column was used. The mobile phase was composed of acetonitrile-phosphoric acid solution with volume fraction of 0.05% (volume ratio 10: 90). The flow rate was 1 mL 路min-1, the detection wavelength was 1: 211 nm, the sample size was 20 渭 L, the column temperature was 35 鈩，

本文編號：1556478