本文關鍵詞： RNA病毒 C蛋白酶 CL蛋白酶 廣譜抑制劑　出處：《國際藥學研究雜志》2016年03期 　論文類型：期刊論文

【摘要】：小RNA病毒和冠狀病毒屬于單正鏈RNA病毒,其家族中的病原體易導致手足口病、心肌炎、普通感冒以及嚴重的呼吸道和腸道疾病。3C和3CL蛋白酶都屬于半胱氨酸蛋白酶,底物結合位點高度保守且具有相似的催化機制,是催化單正鏈RNA病毒前體蛋白裂解的關鍵蛋白酶,對病毒的復制有重要作用。人體中沒有與其相似的蛋白酶,是目前廣譜抗單正鏈RNA病毒研究的重要靶點。利用3C和3CL蛋白酶結構的相同點,成功發(fā)現(xiàn)了具有廣譜作用的蛋白酶抑制劑。本文簡要概述3C和3CL蛋白酶的結構、功能和廣譜抑制劑的研究進展,并簡要闡釋抑制劑的作用機制,對該類酶的廣譜抑制劑研究和相關病毒的治療具有指導意義。
[Abstract]:Small RNA virus and coronavirus belong to single positive strand RNA virus. The pathogens in their family are susceptible to hand, foot and mouth disease, myocarditis, common cold and severe respiratory and intestinal diseases. 3C and 3CL proteases are all cysteine proteases. Substrate binding sites are highly conserved and have similar catalytic mechanisms. They are the key proteases that catalyze the cleavage of single-stranded RNA virus precursor proteins, and play an important role in viral replication. It is an important target in the research of broad-spectrum anti-Monoplar RNA virus. By using the similarities of 3C and 3CL protease structures, a wide spectrum protease inhibitor has been successfully found. In this paper, the structures of 3C and 3CL proteases are briefly summarized. The research progress of functional and broad-spectrum inhibitors, and briefly explain the mechanism of their action, are of guiding significance for the study of broad-spectrum inhibitors of this kind of enzymes and the treatment of related viruses.
【作者單位】： 沈陽藥科大學制藥工程學院;軍事醫(yī)學科學院毒物藥物研究所;
【分類號】：R978.7
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本文編號：1531382