本文關(guān)鍵詞： 明膠空心膠囊 元素 原子熒光光度法 石墨爐原子吸收法 火焰原子吸收法 市售樣品　出處：《中國藥房》2017年28期 　論文類型：期刊論文

【摘要】：目的:為明膠空心膠囊質(zhì)量的提高提供參考。方法:采用原子熒光光度法測(cè)定明膠空心膠囊中汞、砷的含量,石墨爐原子吸收法測(cè)定鉻、鉛和鎘的含量,火焰原子吸收法測(cè)定銅和鋅的含量,并對(duì)48批市售明膠空心膠囊的7種元素含量進(jìn)行測(cè)定。結(jié)果:各元素在各自的檢測(cè)質(zhì)量濃度范圍內(nèi)(鉻、鉛、鎘、砷、汞分別為0~10、0~20、0~1.5、0~10、0~1.0μg/L,銅、鋅均為0~1.8 mg/L)線性關(guān)系良好(r≥0.996 9);鉻、鉛、鎘、銅、鋅、汞、砷檢測(cè)限分別為0.065、0.007、0.011、0.004、0.010、0.108、0.004μg/L;精密度試驗(yàn)的RSD均不大于2.5%(n=6);重復(fù)性試驗(yàn)的RSD均不大于7.5%(n=6);平均加樣回收率在88.6%~109.5%之間,RSD均不大于6.7%(n=6)。48批市售樣品中7種元素含量均符合2015年版《中國藥典》(四部)及其他國家或組織藥典或標(biāo)準(zhǔn)中的相關(guān)規(guī)定。結(jié)論:本方法靈敏度與精密度高、結(jié)果準(zhǔn)確可靠,可用于明膠空心膠囊中鉻、鉛、鎘、銅、鋅、汞、砷7種元素的含量測(cè)定;不同廠家生產(chǎn)的48批明膠空心膠囊質(zhì)量情況較好。
[Abstract]:Objective: to provide a reference for improving the quality of gelatin hollow capsules. Methods: the content of mercury and arsenic in gelatin hollow capsules was determined by atomic fluorescence spectrophotometry, and the content of chromium, lead and cadmium in gelatin hollow capsules was determined by graphite furnace atomic absorption spectrometry. The contents of copper and zinc were determined by flame atomic absorption spectrometry, and the contents of 7 elements in 48 batches of commercial gelatin hollow capsules were determined. Results: each element was in the range of detection mass concentration (chromium, lead, cadmium, arsenic and mercury). The linear relationship of zinc is 0 ~ 1.8 mg / L (r 鈮，

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