發(fā)布時(shí)間：2018-02-13 16:35

  本文關(guān)鍵詞： 阿奇霉素 粉-液雙室袋 傳統(tǒng)粉針　出處：《中國抗生素雜志》2017年08期 　論文類型：期刊論文

【摘要】：目的通過實(shí)驗(yàn)系統(tǒng)評價(jià)新型阿奇霉素粉-液雙室袋的便利性,安全性和準(zhǔn)確性。方法采用計(jì)算配制時(shí)間來評價(jià)雙室袋的便利性;通過對配制過程中出現(xiàn)的刺傷、劃傷等傷害人次,和配制后不溶性微粒數(shù)來評價(jià)雙室袋的安全性;通過高效液相色譜法檢測配制濃度和殘留量來評價(jià)雙室袋配制的準(zhǔn)確性。結(jié)果雙室袋配制時(shí)間明顯少于粉針配制時(shí)間[(22.5±4.7)s vs(89.2±15.5)s,P0.05];配制過程中不會造成人員傷害,配制后的不溶性微粒數(shù)明顯少于粉針配制(P0.05);由于雙室袋配制過程中不產(chǎn)生藥物殘留,故其藥物濃度更接近理論值。結(jié)論新型阿奇霉素粉-液雙室袋在便利性、安全性和準(zhǔn)確性上都明顯優(yōu)于粉針配制,具有顯著的臨床應(yīng)用優(yōu)勢。
[Abstract]:Objective to evaluate the convenience, safety and accuracy of a new type of azithromycin powder / liquid double compartment bag. The safety of double compartment bag was evaluated by scratch injury and the number of insoluble particles after preparation. The accuracy of double chamber bag preparation was evaluated by high performance liquid chromatography (HPLC). Results the preparation time of double chamber bag was significantly shorter than that of powder needle preparation [22. 5 鹵4. 7 s vs(89.2 鹵15. 5 vs(89.2 P 0. 05]. The number of insoluble particles after preparation was obviously less than that of P0.05 prepared by powder needle, and the drug concentration was closer to the theoretical value because there was no drug residue in the preparation of two-compartment bag. Conclusion A new type of azithromycin powder / liquid dual-compartment bag is convenient. Safety and accuracy are obviously superior to the preparation of powder needle, has a significant advantage in clinical application.
【作者單位】： 第三軍醫(yī)大學(xué)大坪醫(yī)院野戰(zhàn)外科研究所第一研究室創(chuàng)傷燒傷與復(fù)合傷國家重點(diǎn)實(shí)驗(yàn)室;
【分類號】：R927.1

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本文編號：1508605