本文關(guān)鍵詞： 硫糖鋁 凝膠 p H 鋁離子　出處：《中國(guó)藥學(xué)雜志》2015年11期 　論文類型：期刊論文

【摘要】：目的硫糖鋁的胃黏膜保護(hù)作用與其在酸性條件下形成不溶性的凝膠有關(guān),但在臨床上硫糖鋁經(jīng)常與抑酸藥合用,而合用的抑酸藥對(duì)硫糖鋁的療效及安全性的影響目前還不清楚。方法通過體外觀察硫糖鋁混懸液凝膠形成的p H及其性狀,了解硫糖鋁發(fā)揮療效的適應(yīng)p H值;以電感耦合等離子發(fā)射光譜(ICP-OES)法測(cè)定上清液中鋁離子濃度,了解硫糖鋁的可能不良作用。結(jié)果硫糖鋁在p H為0.1時(shí)可完全溶解;p H為0.7,1.0和2.0的條件下可形成白色較軟、黏附性強(qiáng)、伸展性佳的凝膠,隨著放置時(shí)間的延長(zhǎng),逐漸形成沉淀;p H≥3.0時(shí)無法形成凝膠;p H4.0時(shí)可形成質(zhì)地較硬、無明顯黏附和伸展性的白色沉淀物。在p H 0.1~7.0內(nèi),隨著p H的升高,游離鋁離子的量逐漸降低。結(jié)論硫糖鋁聯(lián)用抑酸藥不會(huì)增加鋁離子的吸收,但是否具有協(xié)同作用,值得商榷。
[Abstract]:Objective the protective effect of sucralfate on gastric mucosa is related to the formation of insoluble gels under acidic conditions, but it is often combined with acid suppressants in clinical practice. However, the effect of acid-suppressant on the efficacy and safety of sucralfate was not clear. Methods the pH and its properties of sucralfate suspension gel were observed in vitro to understand the adaptive pH value of sucralfate. The concentration of aluminum in supernatant was determined by inductively coupled plasma emission spectrometry (ICP-OES), and the possible adverse effects of sucralfate were investigated. Results when pH was 0.1, sucralfate could be dissolved completely, and pH was 0.71.0 and 2.0 respectively. The gel with strong adhesion and good extensibility is gradually formed when pH 鈮，

本文編號(hào)：1508684