發(fā)布時(shí)間：2018-02-10 22:35

  本文關(guān)鍵詞： 納米凝膠 無皂乳液聚合 藥物載體 溫敏性 靜電吸附　出處：《中國醫(yī)院藥學(xué)雜志》2015年10期 　論文類型：期刊論文

【摘要】：目的:制備離子型N-異丙基丙烯酰胺(NIPAM)類溫敏納米凝膠用于靜電吸附載藥。方法:分別采用乳液聚合(EP)、種子乳液聚合(SEP)和無皂乳液聚合(SFEP)法將NIPAM與丙烯酸(AA)或甲基丙烯酸β-硫酸乙基酯(SEMA)共聚制成納米凝膠,通過TEM、PCS、電位滴定等方法表征各凝膠顆粒的形貌尺寸、溫敏行為及單體含量。以阿霉素為模型藥物,考察納米凝膠通過靜電吸附載藥的能力。結(jié)果:EP或SEP法制備的AA凝膠(PNA)單分散性和溫敏性良好,單體能完全參與聚合,當(dāng)溫度從20℃升至45℃時(shí),粒徑約從100 nm降至50 nm。EP法制備的SEMA凝膠(PNS)單分散性較差,改用SFEP法能提高凝膠的單分散性,但是約40%單體沒有參與共聚。PNS凝膠的溫敏性仍得到保留,20~45℃下粒徑約為200~140 nm。核-殼型納米凝膠的載藥量和包封率最低,隨著交聯(lián)密度的增大,PNA納米凝膠的載藥量也相應(yīng)提高。PNS納米凝膠的載藥量和包封率分別為14.6%和85.3%,載藥能力最強(qiáng),約為PNA納米凝膠的2~3倍。PNS納米凝膠負(fù)載的藥物在純水中24 h不釋放,在生理鹽水中約2 h釋放完全。結(jié)論:PNS納米凝膠粒徑均一,具有溫敏性,載藥性能好,有望成為一個(gè)智能響應(yīng)性納米藥物載體。
[Abstract]:Objective: to prepare ionic N- isopropyl acrylamide (NIPAM)-type thermo-sensitive nanogels for electrostatic adsorption of drugs. Methods: NIPAM and acrylic acid were prepared by emulsion polymerization (EPN), seed emulsion polymerization (SEP) and soap-free emulsion polymerization (Sep) respectively. Nano-gel was prepared by copolymerization of 尾 -ethyl acrylate and SEMA. The morphology, temperature-sensitive behavior and monomer content of each gel particle were characterized by TEMP-PCS and potentiometric titration. Adriamycin was used as the model drug. Results the monodispersity and temperature sensitivity of AA gel prepared by SEP or% EP method were good, and the monomer could participate in the polymerization completely. When the temperature rose from 20 鈩，

本文編號：1501602