本文關(guān)鍵詞：我院378例兒童藥品不良反應(yīng)報(bào)告分析　出處：《中國藥房》2016年08期 　論文類型：期刊論文

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【摘要】：目的:了解我院兒童藥品不良反應(yīng)(ADR)發(fā)生的特點(diǎn)及規(guī)律,以促進(jìn)醫(yī)院兒童安全、合理用藥。方法:采用回顧性分析方法,對(duì)我院2010-2014年上報(bào)國家ADR監(jiān)測(cè)系統(tǒng)的378例兒童ADR報(bào)告進(jìn)行統(tǒng)計(jì)、分析和評(píng)價(jià)。結(jié)果:在378例兒童ADR中,男性患兒255例(67.46%),女性患兒123例(32.54%);1~3歲年齡組患兒ADR發(fā)生率最高(27.51%);靜脈滴注是引發(fā)ADR的最主要給藥途徑,共331例(87.57%);注射用無菌粉末是最主要?jiǎng)┬?有236例(62.43%);引發(fā)ADR最多的藥品品種是抗感染藥(50.26%),而抗感染藥中又以頭孢菌素類為主(43.68%);ADR最常見的臨床表現(xiàn)為皮膚及其附件損害(56.35%),主要表現(xiàn)是皮疹、斑丘疹等過敏樣反應(yīng);大部分ADR經(jīng)過相關(guān)處理后能夠痊愈或者好轉(zhuǎn)(分別占64.29%和34.66%)。結(jié)論:兒童ADR的發(fā)生與給藥途徑、劑型、品種等多種因素密切相關(guān),臨床用藥中需嚴(yán)格掌握藥物的適應(yīng)癥、給藥途徑、方法、速度等,以促進(jìn)臨床合理用藥,減少ADR的發(fā)生。
[Abstract]:Objective: to understand the characteristics and regularity of ADRs in children in our hospital so as to promote the safety and rational use of ADR.Methods: retrospective analysis was used. The ADR reports of 378 children reported to the National ADR Surveillance system in our hospital from 2010 to 2014 were analyzed and evaluated. Results: in 378 children with ADR. 255 cases of male children had 67.46% of them, 123 cases of female children had 32. 54 cases. 1the incidence of ADR in the age group of 3 years old was the highest (27.51%). Intravenous drip was the main route of administration of ADR, which was 87.57% in 331 cases. Sterile powder for injection was the most important dosage form, there were 236 cases. The most common drug causing ADR was the anti-infective drug 50.26, and the antiinfective drug was mainly composed of cephalosporins 43.68%. The most common clinical manifestation of ADR was skin and its adnexal lesions. The main manifestations were allergic reactions such as rashes and papules. Most of ADR can be cured or improved after related treatment (64.29% and 34.666.Conclusion: the occurrence and administration of ADR in children, dosage form. Variety and other factors are closely related to each other. In order to promote the rational use of drugs and reduce the occurrence of ADR, the indications, ways, methods and speed of drug administration should be strictly grasped in clinical use.
【作者單位】： 玉林市第一人民醫(yī)院藥學(xué)部;
【基金】：玉林市科學(xué)研究與技術(shù)開發(fā)項(xiàng)目(No.玉市科攻13071006)
【分類號(hào)】：R969.3
【正文快照】： 藥品不良反應(yīng)(ADR)是指合格藥品在正常用法用量下出現(xiàn)的與用藥目的無關(guān)或意外的有害反應(yīng)。我國每年因ADR入院的患者至少500萬人次,其中50萬人為嚴(yán)重ADR,每年死亡約19萬人,導(dǎo)致醫(yī)療費(fèi)用增加近40億元[1]。兒童的嚴(yán)重ADR報(bào)告占全部嚴(yán)重ADR報(bào)告的13.4%,主要涉及的藥物以抗菌藥物為，

本文編號(hào)：1415221