【摘要】： 目的探討小梁切除術(shù)聯(lián)合絲裂霉素C(MMC)及生物羊膜移植可調(diào)整縫線治療難治性青光眼的效果。方法將接受小梁切除術(shù)的各類型難治性青光眼38例(44眼)分為3組,A組為治療組(16眼),鞏膜瓣下行羊膜移植術(shù)(AMT)聯(lián)合應(yīng)用MMC；B組為MMC組(14眼),鞏膜瓣下聯(lián)合應(yīng)用MMC;C組為對照組(14眼),常規(guī)行單純小梁切除術(shù)；3組病例均留置可調(diào)整縫線。術(shù)后1周、2周、1月、6月、12月觀察記錄術(shù)眼眼壓、濾過泡、前房深度情況及并發(fā)癥。結(jié)果術(shù)后眼壓、濾過泡、前房深度情況及并發(fā)癥治療組、MMC組均好于對照組,組間差異有統(tǒng)計學(xué)意義(P0.01)。術(shù)后并發(fā)癥：治療組少,主要有術(shù)后淺前房；MMC組主要有薄壁濾過泡、濾過泡滲漏等。結(jié)論小梁切除術(shù)聯(lián)合MMC及生物羊膜移植可調(diào)整縫線是治療難治青光眼的一種有效方法,羊膜植入不僅有抗新生血管和抗瘢痕形成的作用,而且早期還有機(jī)械引流的作用。
[Abstract]:Objective To study the effect of trabeculectomy combined with mitomycin C (MMC) and biological amnion transplantation in the treatment of refractory glaucoma. Methods 38 cases of refractory glaucoma with trabeculectomy (44 eyes) were divided into 3 groups, group A was treated group (16 eyes), scleral flap descending amniotic membrane transplantation (AMT) combined with MMC, group B was MMC group (14 eyes), and MMC was used in scleral flap. In group C, the control group (14 eyes) and the conventional simple trabeculectomy were performed, and the adjustable suture was retained in the 3 cases. Intraocular hypertension, bleb, anterior chamber depth and complications were recorded at 1 week,2 weeks, January, June and December after operation. Results The intraocular pressure, the bleb, the depth of the anterior chamber, the treatment group of the complication and the MMC group were better than those in the control group, and the difference between the groups was statistically significant (P0.01). The postoperative complications were as follows: the treatment group was few, mainly had the post-operative shallow anterior chamber; the MMC group mainly had a thin-wall filtration bubble, a filtered bubble leak, and the like. Conclusion Trabeculectomy combined with MMC and bioamnion transplantation can be an effective method for the treatment of refractory glaucoma.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R779.6

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