【摘要】：目的:研究云南地區(qū)人群CDKN2A基因rs1412829多態(tài)性與鼻咽癌的相關性。方法:隨機抽取無血緣關系鼻咽癌患者95例和健康人100例,抽提基因組DNA,采用TaqMan探針基因分型法檢測多態(tài)性。結果:(1)CDKN2A等位基因G在鼻咽癌組和對照組中的分布頻率差異有顯著性(P=0.023),G等位基因攜帶者患鼻咽癌的風險為A等位基因攜帶者的2.497倍(OR=2.497,95%CI=1.107~5.632,P=0.031);(2)鼻咽癌組與對照組AA、AG及GG的基因型頻率分布有統(tǒng)計學差異(P=0.031);(3)鼻咽癌組含有G等位基因的個體病理分期較晚(Ⅳ期),差異有顯著統(tǒng)計學意義(P0.001)。結論:CDKN2A基因rs1412829基因多態(tài)性中G等位基因可能是鼻咽癌的危險因素。該多態(tài)性與病理分期Ⅳ期間存在相關性,可以認為G等位基因突變較易出現(xiàn)在NPC病情發(fā)展的晚期。
[Abstract]:Objective: to study the relationship between rs1412829 polymorphism of CDKN2A gene and nasopharyngeal carcinoma (NPC) in Yunnan population. Methods: 95 unrelated nasopharyngeal carcinoma patients and 100 healthy people were randomly selected. Genomic DNA, was extracted and genotyped by TaqMan probe. Results: (1) there was significant difference in the distribution frequency of CDKN2A allele G between nasopharyngeal carcinoma group and control group (P 鈮，

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