【摘要】：目的研究阻塞性睡眠呼吸暫停低通氣綜合征(OSAHS)患者的睡眠結(jié)構(gòu)紊亂及其對(duì)肝酶水平的影響。方法研究2010—2013年蘇州大學(xué)附屬第二醫(yī)院神經(jīng)內(nèi)科收治的多導(dǎo)睡眠監(jiān)測(cè)(PSG)確診的OSAHS組和對(duì)照組的睡眠參數(shù),且根據(jù)睡眠呼吸暫停和(或)低通氣指數(shù)(AHI)將OSAHS組分為輕、中、重度三組,比較各組間肝酶及睡眠結(jié)構(gòu)的變化,并將肝酶水平與睡眠結(jié)構(gòu)指標(biāo)進(jìn)行相關(guān)性分析。結(jié)果與對(duì)照組比較,OSAHS組患者的AHI、呼吸相關(guān)微覺醒指數(shù)、最長呼吸暫停時(shí)間、睡眠時(shí)間1+2期比例及血清丙氨酸轉(zhuǎn)氨酶(ATL)、天冬氨酸轉(zhuǎn)氨酶(ASL)、血清γ-谷氨酰轉(zhuǎn)肽酶(γ-GGT)水平顯著增高,最低血氧飽和度(L-SaO2)及慢波睡眠比例顯著降低(均P0.05)。OSAHS組各亞組間比較,AHI差異有統(tǒng)計(jì)學(xué)意義;與重度亞組比較,輕、中度亞組呼吸相關(guān)微覺醒指數(shù)、最長呼吸暫停時(shí)間、睡眠時(shí)間1+2期比例、慢波睡眠比例及血清ATL、ASL的變化均有統(tǒng)計(jì)學(xué)意義;與重度亞組比較,輕度亞組的血清γ-GGT顯著升高(P0.05)。偏相關(guān)分析顯示,血清ALT、AST與睡眠1+2期比例呈正相關(guān),血清ALT與慢波睡眠比例呈負(fù)相關(guān),與呼吸睡眠微覺醒呈正相關(guān)(均P0.05)。結(jié)論 OSAHS患者存在睡眠結(jié)構(gòu)紊亂及肝臟損傷,其肝酶水平的升高與睡眠結(jié)構(gòu)紊亂有關(guān)。
[Abstract]:Objective to study the disorder of sleep structure and its effect on liver enzyme level in patients with obstructive sleep Apnea hypopnea syndrome (OSAHS). Methods the sleep parameters of OSAHS group and control group diagnosed by (PSG) were studied in the Department of Neurology, the second affiliated Hospital of Suzhou University from 2010 to 2013. The OSAHS group was divided into mild group according to sleep apnea and / or hypopnea index (AHI). In moderate and severe groups, the changes of liver enzyme and sleep structure were compared, and the correlation between liver enzyme level and sleep structure index was analyzed. Results compared with the control group, the AHI, respiratory related microarousal index, the longest apnea time, the proportion of sleep time in 12 stages and the serum alanine transaminase (ATL), aspartate transaminase (ASL), in the OSAHS group were compared with those in the control group. The level of serum gamma-glutamyl transpeptidase (緯-GGT) was significantly increased, the lowest oxygen saturation (L-SaO2) and the proportion of slow wave sleep were significantly decreased (P 0.05). There was significant difference in AHI among each subgroup of). OSAHS group. Compared with the severe subgroup, the respiratory related microarousal index, the longest apnea time, the proportion of sleep time in 12 stages, the proportion of slow wave sleep and the change of serum ATL,ASL in mild and moderate subgroup were statistically significant. Compared with the severe subgroup, the serum 緯-GGT in the mild subgroup was significantly higher than that in the severe subgroup (P 0.05). Partial correlation analysis showed that serum ALT,AST was positively correlated with the proportion of sleep stage 12, serum ALT was negatively correlated with the proportion of slow wave sleep, and positively correlated with respiratory sleep microarousal (all P 0.05). Conclusion there are sleep structure disorder and liver injury in patients with OSAHS, and the increase of liver enzyme level is related to sleep structure disorder.
【作者單位】： 蘇州大學(xué)附屬第二醫(yī)院神經(jīng)內(nèi)科;
【基金】：國家自然科學(xué)基金(81200894) 教育部高等學(xué)校博士學(xué)科點(diǎn)專項(xiàng)科研基金(20113201120016)
【分類號(hào)】：R766
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本文編號(hào)：2483458