低相對(duì)分子量殼聚糖修飾的醋甲唑胺固體脂質(zhì)納米粒對(duì)治療青光眼的體內(nèi)外效果
發(fā)布時(shí)間：2019-03-17 07:42
【摘要】：正通過(guò)改良的化學(xué)氧化降解法得到低相對(duì)分子量殼聚糖(CS)。采用改良的乳化-溶劑揮發(fā)法制備采用及未用上述CS修飾的醋甲唑胺固體脂質(zhì)納米粒(CS-SLN-MTZ和SLN-MTZ),結(jié)果兩種制品的平均粒徑為(252.8±4.0)和(199.4±2.8)nm,ζ電位為(+31.3±1.7)和(-21.3±1.9)mV。物理穩(wěn)定性研究表明,CS-SLN-MTZ在4℃下能維持穩(wěn)定4個(gè)月以上,而SLN-MTZ則不超過(guò)2個(gè)月。體外研究表明,相對(duì)于SLN-MTZ,CS-SLN-
[Abstract]:Preparation of low molecular weight chitosan (CS). By modified chemical oxidation degradation Solid lipid nanoparticles (CS-SLN-MTZ and SLN-MTZ) modified with or without CS were prepared by modified emulsion-solvent evaporation method. Results the average particle sizes of the two products were (252.8 鹵4.0) and (199.4 鹵2.8) nm, 味 potentials were (31.3 鹵1.7) and (- 21.3 鹵1.9) mV. respectively. The physical stability study shows that CS-SLN-MTZ can keep stable for more than 4 months at 4 鈩，
本文編號(hào)：2442074
[Abstract]:Preparation of low molecular weight chitosan (CS). By modified chemical oxidation degradation Solid lipid nanoparticles (CS-SLN-MTZ and SLN-MTZ) modified with or without CS were prepared by modified emulsion-solvent evaporation method. Results the average particle sizes of the two products were (252.8 鹵4.0) and (199.4 鹵2.8) nm, 味 potentials were (31.3 鹵1.7) and (- 21.3 鹵1.9) mV. respectively. The physical stability study shows that CS-SLN-MTZ can keep stable for more than 4 months at 4 鈩，
本文編號(hào)：2442074
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