TNFAIP3基因在放射治療鼻咽癌中的表達(dá)及意義
發(fā)布時(shí)間：2018-10-24 08:00
【摘要】：背景與目的:鼻咽癌多對(duì)放射治療敏感,研究鼻咽癌放療抗拒具有重要意義。本研究旨在探討腫瘤壞死因子α誘導(dǎo)蛋白3(tumor necrosis factor alpha induced protein 3,TNFAIP3)在經(jīng)放射治療的鼻咽癌中的表達(dá),分析其在放療敏感及放療抗拒的鼻咽癌中表達(dá)的差異,與放療抗拒發(fā)生、發(fā)展的關(guān)系。方法:采用TNFAIP3多點(diǎn)標(biāo)記的地高辛探針原位雜交方法檢測(cè)TNFAIP3 m RNA在放療敏感及放療抗拒的鼻咽癌中的表達(dá)。結(jié)果:TNFAIP3 m RNA中度及強(qiáng)陽(yáng)性表達(dá)率在放療敏感及放療抗拒的鼻咽癌中的表達(dá)率分別為15.00%和45.00%,差異有統(tǒng)計(jì)學(xué)意義(χ2=5.274,P=0.0216)。在放療抗拒的鼻咽癌中,TNFAIP3 m RNA中度及強(qiáng)陽(yáng)性表達(dá)率與TNM分期呈正相關(guān),Ⅲ~Ⅳ期TNFAIP3 m RNA中度及強(qiáng)陽(yáng)性表達(dá)率為48.28%,I~Ⅱ期表達(dá)率為36.36%,差異有統(tǒng)計(jì)學(xué)意義(χ2=33.240,P0.005);在有、無(wú)遠(yuǎn)處轉(zhuǎn)移中的表達(dá)率分別為81.81%和31.03%,差異有統(tǒng)計(jì)學(xué)意義(χ2=6.385,P=0.011 5)。結(jié)論:TNFAIP3雖具有抗腫瘤效應(yīng),但參與了放療抗拒的鼻咽癌的發(fā)生、發(fā)展。
[Abstract]:Background & objective: nasopharyngeal carcinoma is sensitive to radiotherapy, so it is important to study radiotherapy resistance of nasopharyngeal carcinoma. The purpose of this study was to investigate the expression of tumor necrosis factor-alpha inducible protein 3 (tumor necrosis factor alpha induced protein 3 (TNFAIP3) in radiotherapy of nasopharyngeal carcinoma (NPC), and to analyze the difference between the expression of TNF- 偽 -inducible protein 3 (tumor necrosis factor alpha induced protein 3 and radiotherapy resistant nasopharyngeal carcinoma (NPC) and the occurrence of radiotherapy resistance. The relationship between development Methods: the expression of TNFAIP3 m RNA in radiotherapy sensitive and radiotherapy resistant nasopharyngeal carcinoma (NPC) was detected by in situ hybridization with TNFAIP3 multipoint digoxin probe. Results: the positive expression rates of TNFAIP3 m RNA were 15.00% and 45.00% in radiotherapy sensitive and radiotherapy resistant nasopharyngeal carcinoma, respectively. The difference was statistically significant (蠂 2, 5.274, P < 0.0216). The moderate and strong positive expression rates of TNFAIP3 m RNA in radiotherapy resistant nasopharyngeal carcinoma were positively correlated with TNM stage, and the positive expression rates of TNFAIP3 m RNA in stage 鈪，
本文編號(hào)：2290797
[Abstract]:Background & objective: nasopharyngeal carcinoma is sensitive to radiotherapy, so it is important to study radiotherapy resistance of nasopharyngeal carcinoma. The purpose of this study was to investigate the expression of tumor necrosis factor-alpha inducible protein 3 (tumor necrosis factor alpha induced protein 3 (TNFAIP3) in radiotherapy of nasopharyngeal carcinoma (NPC), and to analyze the difference between the expression of TNF- 偽 -inducible protein 3 (tumor necrosis factor alpha induced protein 3 and radiotherapy resistant nasopharyngeal carcinoma (NPC) and the occurrence of radiotherapy resistance. The relationship between development Methods: the expression of TNFAIP3 m RNA in radiotherapy sensitive and radiotherapy resistant nasopharyngeal carcinoma (NPC) was detected by in situ hybridization with TNFAIP3 multipoint digoxin probe. Results: the positive expression rates of TNFAIP3 m RNA were 15.00% and 45.00% in radiotherapy sensitive and radiotherapy resistant nasopharyngeal carcinoma, respectively. The difference was statistically significant (蠂 2, 5.274, P < 0.0216). The moderate and strong positive expression rates of TNFAIP3 m RNA in radiotherapy resistant nasopharyngeal carcinoma were positively correlated with TNM stage, and the positive expression rates of TNFAIP3 m RNA in stage 鈪，
本文編號(hào)：2290797
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