【摘要】：目的:研究那他霉素滴眼液對(duì)真菌性角膜潰瘍的臨床治療效果,探討真菌性角膜潰瘍的現(xiàn)代診斷與治療手段。 方法:對(duì)60例(60眼)已確診為真菌性角膜潰瘍的23～69歲的患者隨機(jī)分為治療組30例(30眼)與對(duì)照組30例(30眼)。對(duì)照組應(yīng)用氟康唑及碘酊燒灼法,治療組同時(shí)給予那他霉素滴眼液,對(duì)兩組患者治療2個(gè)月后的療程和療效進(jìn)行比較。采用德國(guó)海德堡共焦激光顯微鏡對(duì)比分析真菌菌絲的數(shù)量變化。對(duì)于數(shù)據(jù)結(jié)果進(jìn)行統(tǒng)計(jì)學(xué)分析,應(yīng)用SPSS軟件進(jìn)行統(tǒng)計(jì)學(xué)處理,結(jié)果以P0.05為差異有統(tǒng)計(jì)學(xué)意義。 結(jié)果:(1)療程方面:治療組2個(gè)月內(nèi)治愈21例,療程29～55d,平均44.02±7.59d。對(duì)照組2個(gè)月內(nèi)治愈12例,療程43～60d,平均51.95±8.35d。兩組對(duì)比差異具有統(tǒng)計(jì)學(xué)意義(P0.05),治療組優(yōu)于對(duì)照組。(2)療效方面:治療組輕型8眼,治愈8眼;中型15眼,治愈11眼,顯效2眼,有效2眼;重型7眼,治愈2眼,顯效2眼,有效2眼,無(wú)效1眼。對(duì)照組輕型8眼,治愈8眼;中型14眼,治愈4眼,顯效4眼,有效4眼,無(wú)效2眼;重型8眼,有效3眼,無(wú)效5眼。兩組有效率對(duì)比差異具有統(tǒng)計(jì)學(xué)意義(P0.05),治療組優(yōu)于對(duì)照組。 結(jié)論:那他霉素聯(lián)合氟康唑及碘酊燒灼是治療真菌性角膜潰瘍的有效方法,有助于縮短療程、提高治療的有效率,為治療真菌性角膜潰瘍提供了一種理想的治療方案。
[Abstract]:Objective:To study the clinical effect of Natamycin eye drops on fungal corneal ulcer and to explore the modern diagnosis and treatment of fungal corneal ulcer.
Methods: 60 patients (60 eyes) with fungal corneal ulcer were randomly divided into treatment group (30 eyes) and control group (30 eyes). The control group was treated with fluconazole and iodine tincture cauterization, and the treatment group was treated with natamycin eye drops at the same time. Deborough confocal laser microscopy was used to analyze the changes of mycelium number. Statistical analysis was made on the data and SPSS software was used to analyze the results. The difference was statistically significant with P 0.05.
Results: (1) In the treatment group, 21 cases were cured within 2 months, the treatment course was 29-55 days, the average was 44.02+7.59 days. Effective 2 eyes, effective 2 eyes; severe 7 eyes, cured 2 eyes, markedly effective 2 eyes, effective 2 eyes, ineffective 1 eye. Control group light 8 eyes, cured 8 eyes; medium 14 eyes, cured 4 eyes, markedly effective 4 eyes, effective 4 eyes, ineffective 2 eyes; severe 8 eyes, effective 3 eyes, ineffective 5 eyes.
Conclusion: Natamycin combined with fluconazole and iodine tincture is an effective method to treat fungal corneal ulcer. It is helpful to shorten the course of treatment and improve the efficiency of treatment.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類號(hào)】：R772.21

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