【摘要】：目的探討甲狀腺相關眼病(thyroid associated ophthalmopathy,TAO)患者干眼癥的患病率及不同時期干眼癥患病率的差異和特征。方法收集2014年1月至2014年12月281例TAO患者的資料,包括癥狀、淚液分泌試驗(Schirmer I test,SIt)、淚膜破裂時間(break-up time,BUT)及角膜熒光素染色(fluorescent staining,FS)的結果。按照TAO臨床活動度評分(clinical activity score,CAS),將患者分為活動期(CAS≥4分)和非活動期(CAS4分),根據(jù)TAO病程將患者分為短病程組(1 a)、中病程組(≥1~2 a)、長病程組(≥2 a)。分析干眼癥患病率及特征。結果本組281例TAO患者干眼癥患病率65.48%。活動期和非活動期干眼癥患病率分別為77.08%和59.46%(χ2=8.685,P=0.003),SIt、BUT及FS評分差異均有統(tǒng)計學意義(均為P0.05)。短病程組和長病程組干眼癥患病率分別為68.89%和50.91%(χ2=5.961,P=0.015),病程越長FS評分越小,FS評分差異有統(tǒng)計學意義(P0.05),但SIt及BUT組間差異均無統(tǒng)計學意義(均為P0.05)。結論 TAO患者干眼癥患病率高,活動期和非活動期、不同病程時期患病率存在差異。病程在2 a以上者干眼癥患病率降低。
[Abstract]:Objective to investigate the prevalence and characteristics of dry eye disease (thyroid associated ophthalmopathy,TAO) in patients with thyroid associated ophthalmopathy. Methods data of 281 patients with TAO from January 2014 to December 2014 were collected, including symptoms, tear secretion test (Schirmer I test,SIt), lacrimal film rupture time (break-up time,BUT) and corneal fluorescein staining (fluorescent staining,FS). According to TAO's clinical activity score (clinical activity score,CAS), patients were divided into active period (CAS 鈮，

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