【摘要】：目的觀察玻璃體內注射雷珠單抗聯(lián)合玻璃體切割術治療嚴重增生型糖尿病視網膜病變(proliferative diabetic retinopathy,PDR)的臨床效果。方法將臨床確診為嚴重PDR的患者52例72眼納入本研究。依據(jù)術前是否行玻璃體內注射雷珠單抗將患者分為治療組和對照組:治療組30例42眼、對照組22例30眼。治療組術前3 d玻璃體內注射10 g·L-1雷珠單抗0.05 mL(0.5 mg),然后行玻璃體切割術,對照組直接行玻璃體切割術。術后隨訪3~12(6.5±1.3)個月。對比分析兩組患者視力、眼壓、黃斑中心凹視網膜厚度和術后并發(fā)癥的發(fā)生情況。結果治療組、對照組手術后視力分別為0.090±0.068、0.060±0.029,均較術前提高,2組治療前、治療后視力比較差異均有統(tǒng)計學意義(t=-5.005、-3.237,均為P0.05)。兩組術后視力比較,差異有統(tǒng)計學意義(t=2.034,P0.05)。治療組、對照組術后黃斑中心凹視網膜厚度分別為(313.8±27.3)μm、(325.6±14.5)μm,差異有統(tǒng)計學意義(t=-1.51,P0.05)。術后2周、1個月、3個月,治療組玻璃體積血發(fā)生率分別為12%、2%、2%,對照組發(fā)生率分別為27%、20%、3%;兩組術后各時間點發(fā)生率比較,術后2周及1個月之間差異均有統(tǒng)計學意義(χ2=3.42、3.21,均為P0.05),術后3個月差異無統(tǒng)計學意義(χ2=1.02,P0.05)。結論玻璃體切割術聯(lián)合玻璃體內注射雷珠單抗治療嚴重PDR能提高患者視力,降低術后玻璃體積血發(fā)生率和黃斑中心凹視網膜厚度。
[Abstract]:Objective to observe the clinical effect of intravitreous injection of Leizhu monoclonal antibody combined with vitrectomy in the treatment of severe proliferative diabetic retinopathy (proliferative diabetic retinopathy). Methods 52 cases (72 eyes) with severe PDR were included in this study. The patients were divided into treatment group (n = 30) and control group (n = 42) according to whether intravitreous injection of Lei Zhu McAb was performed before operation: treatment group (n = 30) and control group (n = 22) (30 eyes). The treatment group was treated with vitrectomy 3 days before operation, and the control group was directly treated with vitrectomy. The treatment group was injected with 10 g L -1 Lei Zhu McAb 0. 05 mL (0. 5 mg),) and the control group was directly treated with vitrectomy. Postoperative follow-up was 3 weeks (6.5 鹵1.3) months. Visual acuity, intraocular pressure, macular central foveal retinal thickness and postoperative complications were compared between the two groups. Results the visual acuity of the treatment group and the control group were 0.090 鹵0.068 and 0.060 鹵0.029, respectively, which were significantly higher than those of the two groups before and after treatment (tng-5.005- 3.237, P0.05). The postoperative visual acuity of the two groups was significantly different (t = 2.034 P 0.05). The retinal thickness of macular fovea was (313.8 鹵27.3) 渭 m and (325.6 鹵14.5) 渭 m in the treatment group and control group, respectively. At 2 weeks, 1 month, 3 months after operation, the incidence of vitreous hemorrhage in the treatment group was 12 and that in the control group was 27. 20 and 3, respectively. The difference between 2 weeks and 1 month after operation was statistically significant (蠂 2 + 3.42 鹵3. 21, P0.05), but there was no significant difference 3 months after operation (蠂 2 + 1. 02 P 0.05). Conclusion vitrectomy combined with intravitreous injection of Lei Zhu McAb can improve the visual acuity and decrease the incidence of vitreous hemorrhage and retinal thickness of macular central fovea in patients with severe PDR.
【作者單位】： 石河子大學醫(yī)學院第一附屬醫(yī)院眼科;
【基金】：石河子大學醫(yī)學院第一附屬醫(yī)院院級課題(編號:YL2010-Y003)~~
【分類號】：R779.6;R587.2

【相似文獻】

相關期刊論文 前7條

1 孫克清;麥慶怡;程浩;李玉娟;;糖尿病視網膜病變玻璃體切割術前激光治療[J];國際眼科雜志;2008年12期

2 李旭東;;曲安奈德引導玻璃體切割術治療糖尿病視網膜病變效果觀察[J];中國鄉(xiāng)村醫(yī)藥;2012年16期

3 姜旭光;程希;趙君麗;;中西醫(yī)治療糖尿病性視網膜病變進展[J];河南中醫(yī);2013年12期

4 齊黔方;史要武;郭濤;;增殖性糖尿病視網膜病變術前應用貝伐單抗的臨床觀察[J];國際眼科雜志;2014年09期

5 馮小志;;增殖期糖尿病性視網膜病變的臨床分析[J];吉林醫(yī)學;2011年19期

6 梁靜;陳松;王明儉;;糖尿病性視網膜病變治療進展[J];臨床眼科雜志;2008年01期

7 ;[J];;年期

相關會議論文 前1條

1 孫鵬;劉哲麗;張含;谷峰;;超聲乳化聯(lián)合玻璃體切割術治療增生性糖尿病視網膜病變的手術后并發(fā)癥研究[A];中國眼底病論壇·全國眼底病專題學術研討會論文匯編[C];2008年

，

本文編號：2166172