變應(yīng)性鼻炎患者血清IL-12和IL-27的表達(dá)水平及其意義初探
發(fā)布時(shí)間：2018-07-31 07:19
【摘要】：目的：通過(guò)研究接受和未經(jīng)免疫治療的變應(yīng)性鼻炎患者血清中IL-12和IL-27的水平,并分析IL-12和IL-27兩者的相關(guān)性,探討IL-12和IL-27在變應(yīng)性鼻炎的發(fā)病機(jī)制和治療中的作用。 方法：選擇接受免疫治療2年以上的變應(yīng)性鼻炎患者20例為免疫治療組,未經(jīng)免疫治療的變應(yīng)性鼻炎患者20例為未治療組,以20例無(wú)變態(tài)反應(yīng)疾病的健康人為對(duì)照組。三組間年齡和性別均無(wú)顯著差異,受檢前二周內(nèi)均未使用類(lèi)固醇激素。對(duì)免疫治療組和未治療組的變應(yīng)性鼻炎患者進(jìn)行癥狀和體征評(píng)分。用ELISA法檢測(cè)三組血清中IL-12和IL-27的水平。采用SPSS16.0統(tǒng)計(jì)軟件進(jìn)行統(tǒng)計(jì)分析。 結(jié)果：1.免疫治療組的癥狀和體征記分(6.95±1.19)明顯低于未治療組(9.80±1.98),兩者比較有統(tǒng)計(jì)學(xué)意義(P0.05)。2.IL-12水平：變應(yīng)性鼻炎患者未治療組、免疫治療組和正常對(duì)照組的血清IL-12濃度分別為(111.82±41.32pg/ml)、(163.78±51.76pg/ml)和(207.28±73.90pg/ml),變應(yīng)性鼻炎兩組均顯著低于正常對(duì)照組,未治療組顯著低于免疫治療組,兩兩之間比較有統(tǒng)計(jì)學(xué)意義(P0.05)。3.IL-27水平：變應(yīng)性鼻炎患者未治療組、免疫治療組和正常對(duì)照組的血清IL-27濃度分別為(287.72±1 07.97pg/m1)(403.85±155.59pg/ml)和(622.65±237.87pg/ml),變應(yīng)性鼻炎兩組均顯著低于正常對(duì)照組,免疫治療組血清IL-27濃度高于未治療組,兩兩之間比較有統(tǒng)計(jì)學(xué)意義(P0.05)。4.IL-27和IL-12水平有一定正相關(guān)性(r=0.343)。 結(jié)論：1.變應(yīng)性鼻炎患者血清中IL-12和IL-27水平顯著低于正常人,表明IL-12和IL-27在變應(yīng)性鼻炎的發(fā)病機(jī)制中起作用。2.經(jīng)免疫治療癥狀和體征獲得改善的變應(yīng)性鼻炎患者,血清中IL-12和IL-27水平顯著高于未經(jīng)治療的患者,表明IL-12和IL-27可能在變應(yīng)性鼻炎免疫治療中發(fā)揮免疫調(diào)節(jié)作用。3.IL-27與IL-12在變應(yīng)性鼻炎患者血清中的表達(dá)水平有一定正相關(guān)性,提示IL-27可能在變應(yīng)性鼻炎的發(fā)病機(jī)制中與IL-12發(fā)揮相似的作用,IL-27有可能作為治療變應(yīng)性鼻炎的新靶點(diǎn)。
[Abstract]:Objective: to study the levels of IL-12 and IL-27 in serum of allergic rhinitis treated with or without immunotherapy, and to analyze the relationship between IL-12 and IL-27, and to explore the role of IL-12 and IL-27 in the pathogenesis and treatment of allergic rhinitis. Methods: twenty patients with allergic rhinitis who received immunotherapy for more than 2 years were selected as immunotherapy group, 20 patients with allergic rhinitis without immunotherapy as untreated group and 20 healthy persons without allergic disease as control group. There was no significant difference in age and sex among the three groups. The symptoms and signs of allergic rhinitis in immunotherapy group and untreated group were evaluated. The levels of IL-12 and IL-27 in serum of the three groups were detected by ELISA method. SPSS16.0 statistical software was used for statistical analysis. The result is 1: 1. The score of symptoms and signs in immunotherapy group (6.95 鹵1.19) was significantly lower than that in untreated group (9.80 鹵1.98). The serum IL-12 concentrations in immunotherapy group and normal control group were (111.82 鹵41.32pg/ml), (163.78 鹵51.76pg/ml) and (207.28 鹵73.90pg/ml), respectively. The levels of serum IL-12 in allergic rhinitis group were significantly lower than those in normal control group, and those in untreated group were significantly lower than those in immunotherapy group. The levels of IL-27 in patients with allergic rhinitis were (287.72 鹵1 07.97pg/m1) (403.85 鹵155.59pg/ml) and (622.65 鹵237.87pg/ml), respectively. The levels of IL-27 in patients with allergic rhinitis were (287.72 鹵1 07.97pg/m1) and (622.65 鹵237.87pg/ml), respectively. The levels of IL-27 in allergic rhinitis group were significantly lower than those in normal control group. The level of serum IL-27 in immunotherapy group was higher than that in untreated group (P0.05). 4. There was a positive correlation between IL-27 and IL-12 (r = 0.343). Conclusion 1. The serum levels of IL-12 and IL-27 in patients with allergic rhinitis were significantly lower than those in normal subjects, indicating that IL-12 and IL-27 play an important role in the pathogenesis of allergic rhinitis. The serum levels of IL-12 and IL-27 in allergic rhinitis patients with improved symptoms and signs after immunotherapy were significantly higher than those without treatment. These results suggest that IL-12 and IL-27 may play an immunomodulatory role in the immunotherapy of allergic rhinitis. 3. IL-27 is positively correlated with the expression of IL-12 in serum of patients with allergic rhinitis. It is suggested that IL-27 may play a similar role with IL-12 in the pathogenesis of allergic rhinitis. IL-27 may be a new target for the treatment of allergic rhinitis.
【學(xué)位授予單位】：中南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2011
【分類(lèi)號(hào)】：R765.21
本文編號(hào)：2154843
[Abstract]:Objective: to study the levels of IL-12 and IL-27 in serum of allergic rhinitis treated with or without immunotherapy, and to analyze the relationship between IL-12 and IL-27, and to explore the role of IL-12 and IL-27 in the pathogenesis and treatment of allergic rhinitis. Methods: twenty patients with allergic rhinitis who received immunotherapy for more than 2 years were selected as immunotherapy group, 20 patients with allergic rhinitis without immunotherapy as untreated group and 20 healthy persons without allergic disease as control group. There was no significant difference in age and sex among the three groups. The symptoms and signs of allergic rhinitis in immunotherapy group and untreated group were evaluated. The levels of IL-12 and IL-27 in serum of the three groups were detected by ELISA method. SPSS16.0 statistical software was used for statistical analysis. The result is 1: 1. The score of symptoms and signs in immunotherapy group (6.95 鹵1.19) was significantly lower than that in untreated group (9.80 鹵1.98). The serum IL-12 concentrations in immunotherapy group and normal control group were (111.82 鹵41.32pg/ml), (163.78 鹵51.76pg/ml) and (207.28 鹵73.90pg/ml), respectively. The levels of serum IL-12 in allergic rhinitis group were significantly lower than those in normal control group, and those in untreated group were significantly lower than those in immunotherapy group. The levels of IL-27 in patients with allergic rhinitis were (287.72 鹵1 07.97pg/m1) (403.85 鹵155.59pg/ml) and (622.65 鹵237.87pg/ml), respectively. The levels of IL-27 in patients with allergic rhinitis were (287.72 鹵1 07.97pg/m1) and (622.65 鹵237.87pg/ml), respectively. The levels of IL-27 in allergic rhinitis group were significantly lower than those in normal control group. The level of serum IL-27 in immunotherapy group was higher than that in untreated group (P0.05). 4. There was a positive correlation between IL-27 and IL-12 (r = 0.343). Conclusion 1. The serum levels of IL-12 and IL-27 in patients with allergic rhinitis were significantly lower than those in normal subjects, indicating that IL-12 and IL-27 play an important role in the pathogenesis of allergic rhinitis. The serum levels of IL-12 and IL-27 in allergic rhinitis patients with improved symptoms and signs after immunotherapy were significantly higher than those without treatment. These results suggest that IL-12 and IL-27 may play an immunomodulatory role in the immunotherapy of allergic rhinitis. 3. IL-27 is positively correlated with the expression of IL-12 in serum of patients with allergic rhinitis. It is suggested that IL-27 may play a similar role with IL-12 in the pathogenesis of allergic rhinitis. IL-27 may be a new target for the treatment of allergic rhinitis.
【學(xué)位授予單位】：中南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2011
【分類(lèi)號(hào)】：R765.21
【引證文獻(xiàn)】
相關(guān)碩士學(xué)位論文 前1條
1 馬艷;2%碳酸氫鈉液對(duì)變應(yīng)性鼻炎鼻黏膜的影響及IL-4、IL-10的表達(dá)[D];青海大學(xué);2012年
，本文編號(hào)：2154843
本文鏈接：http://sikaile.net/yixuelunwen/yank/2154843.html
最近更新
教材專(zhuān)著
