【摘要】：目的探討人乳頭狀瘤病毒(Human Papillomavirus,HPV)在鼻息肉(Nasal Polyps)中感染亞型的分布及其在病變發(fā)生、發(fā)展中的作用。 方法取204例鼻息肉石蠟包埋組織標(biāo)本采用核酸分子快速導(dǎo)流雜交基因芯片分型技術(shù)(HybriMax)對37種HPV亞型同步進(jìn)行檢測和病毒分型,并以36例正常鼻腔黏膜組織為對照。 結(jié)果鼻息肉組中HPV總陽性率40.2%(82/204),對照組均為陰性(0/36),鼻息肉組HPV感染率較對照組明顯增高(P0.05),HPV感染亞型以HPV11型為主(45.28%);鼻息肉組織中HPV感染存在單一亞型或混合亞型感染,但以單一亞型感染為主(74.39%);鼻息肉組中性別、年齡、手術(shù)次數(shù)、病程與HPV感染及其高、低危亞型分布無明顯統(tǒng)計學(xué)差異。 結(jié)論鼻息肉的發(fā)生、發(fā)展與HPV感染密切相關(guān),鼻息肉中HPV高、低危亞型均可感染,但以低危亞型(HPV11型)感染為主。
[Abstract]:Objective to investigate the distribution of Human Papillomavirus (HPV) in nasal polyps (Nasal Polyps) and its role in the development and progression of the disease.
Methods 204 cases of paraffin embedded tissue specimens of nasal polyps were detected by nucleic acid molecular rapid flow hybridization gene chip typing (HybriMax) and 37 types of HPV subtypes were synchronously detected and virus typing, and 36 normal nasal mucosa tissues were used as control.
Results the total positive rate of HPV in the nasal polyp group was 40.2% (82/204), and the control group was negative (0/36). The HPV infection rate in the nasal polyp group was significantly higher than that in the control group (P0.05), and the HPV infection subtype was dominated by HPV11 type (45.28%); HPV infection in nasal polyps had a single subtype or mixed subtype infection, but the single subtype infection was the main (74.39%); nasal polyp group was neutral. There was no significant difference in age, number of operations, course of disease and HPV infection and the distribution of high and low risk subtypes.
Conclusion the occurrence and development of nasal polyps are closely related to HPV infection. HPV is high and low risk subtypes can be infected in nasal polyps, but mainly in low risk subtypes (type HPV11).
【學(xué)位授予單位】：寧夏醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2011
【分類號】：R765.25

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