本文選題：Avastin + 綠激光��； 參考：《中國醫(yī)科大學(xué)》2010年碩士論文

【摘要】： 目的 評價avastin玻璃體腔內(nèi)注射聯(lián)合綠激光治療缺血型視網(wǎng)膜中央靜脈阻塞引發(fā)黃斑水腫的臨床療效。 方法 對于2008年10月到2009年10月收治的24例26眼依據(jù)眼底熒光血管造影(FFA)結(jié)果,被確診為缺血型視網(wǎng)膜中央靜脈阻塞并伴發(fā)黃斑水腫,隨機(jī)分為avastin玻璃體腔內(nèi)注射聯(lián)合綠激光治療組和單純激光治療對照組,隨訪6個月,隨訪視力、眼壓、眼部情況,并行眼底照片、熒光血管造影和光學(xué)相干斷層掃描(OCT)。 結(jié)果 OCT檢查14例患者平均黃斑區(qū)厚度術(shù)(CFT)術(shù)前為584.36±114.76um,術(shù)后1月黃斑水腫消退為11只眼,消退率為79%。術(shù)后3個月黃斑水腫消退為11只眼,消退率為79%.術(shù)后6個月黃斑水腫消退10只眼,消退率為71%。對照組中術(shù)前OCT顯示黃斑中心凹厚度450-748μm(平均599μm),手術(shù)后1個月OCT顯示黃斑水腫消退為4只,消退率為33%.術(shù)后3個月黃斑水腫消退為4只眼,消退率為33%.術(shù)后6個月黃斑水腫消退為3只眼,消退率為25%。(消退：OCT證實黃斑區(qū)視網(wǎng)膜厚度減低大于100μm；不變：OCT證實黃斑區(qū)視網(wǎng)膜厚度減低小于100μm).術(shù)后1個月,實驗組12例14只眼中12只眼視力有提高,提高率86%,2只眼視力無變化。對照組12只眼中4只眼視力有提高,提高率33%,5只眼視力無變化,3只眼視力下降。術(shù)后視力實驗組明顯高于對照組(χ2=7.490,P=0.006,Fisher確切檢驗法)。術(shù)后3個月,實驗組12例14只眼中11只眼視力有提高,提高率79%,3只眼視力無變化。對照組12只眼中4只眼視力有提高,提高率33%,5只眼視力無變化,3只眼視力下降。術(shù)后視力實驗組明顯高于對照]組(χ2=5.418,P=0.02,Fisher確切檢驗法)。術(shù)后6個月,實驗組12例14只眼中10只眼視力有提高,提高率71%,4只眼視力無變化。對照組12只眼中3只眼視力有提高,提高率25%,4只眼視力無變化,5只眼視力下降。術(shù)后視力實驗組明顯高于對照組(χ2=5.571,P=0.018,Fisher確切檢驗法)。(視力提高2行是提高,1行波動是為無變化,下降1行視為無變化。)兩組均無眼壓升高者。所得數(shù)據(jù)均有統(tǒng)計學(xué)意義。 結(jié)論 avastin玻璃體腔內(nèi)注射聯(lián)合綠激光治療缺血型視網(wǎng)膜中央靜脈阻塞黃斑水腫在較短的時間內(nèi)比較單純激光治療缺血性視網(wǎng)膜中央靜脈阻塞,更有效的提高視力,促進(jìn)黃斑水腫的吸收。
[Abstract]:Objective to evaluate the clinical effect of intravitreal injection of avastin combined with green laser in the treatment of macular edema caused by ischemic central retinal vein occlusion. Methods from October 2008 to October 2009, 26 eyes of 24 patients were diagnosed as ischemic central retinal vein occlusion with macular edema according to the results of fundus fluorescein angiography (FFA). Avastin intravitreal injection combined with green laser was randomly divided into two groups. The patients were followed up for 6 months. The visual acuity, intraocular pressure, ocular conditions, fundus photographs, fluorescein angiography and optical coherence tomography (Oct) were followed up. Results the mean macular area thickness (CFT) was 584.36 鹵114.76 umum before Oct in 14 patients, and macular edema subsided in 11 eyes one month after Oct, the regression rate was 79. Macular edema subsided in 11 eyes 3 months after operation, the regression rate was 79g. Macular edema disappeared in 10 eyes 6 months after operation, the regression rate was 71. In the control group, preoperative Oct showed macular fovea thickness 450-748 渭 m (mean 599 渭 m),). Oct showed macular edema subsided in 4 rats, and the regression rate was 33%. Macular edema subsided in 4 eyes 3 months after operation, and the regression rate was 33%. Macular edema subsided in 3 eyes 6 months after operation, and the regression rate was 25%. Regression: Oct confirmed macular retinal thickness reduction greater than 100 渭 m; invariant Oct confirmed macular retinal thickness reduction less than 100 渭 m). One month after operation, the visual acuity of 12 eyes of 14 eyes of 12 cases in the experimental group was improved, and the improvement rate of 86% was unchanged in 2 eyes. In the control group, the visual acuity was improved in 4 eyes in 12 eyes and the visual acuity in 3 eyes was decreased in 3 eyes. Postoperative visual acuity in the experimental group was significantly higher than that in the control group (蠂 ~ 2 / 7.490). Three months after operation, the visual acuity of 11 eyes of 12 cases (14 eyes) in the experimental group was improved, and the improvement rate was 79% (3 eyes). In the control group, the visual acuity was improved in 4 eyes in 12 eyes and the visual acuity in 3 eyes was decreased in 3 eyes. The postoperative visual acuity in the experimental group was significantly higher than that in the control group (蠂 ~ 2 = 5.418). Six months after operation, the visual acuity of 10 eyes in 14 eyes of 12 cases in the experimental group was improved, the improvement rate was 71% and 4 eyes did not change. In control group, visual acuity was improved in 3 eyes in 12 eyes, and the visual acuity was decreased in 5 eyes in 4 eyes of 25 eyes. Postoperative visual acuity in the experimental group was significantly higher than that in the control group (蠂 2 / 5.571). Visual acuity improved by 2 lines is improved by 1 row fluctuation is no change, and decreased by 1 line is regarded as no change. There was no elevation of intraocular pressure in both groups. The data were statistically significant. Conclusion avastin intravitreal injection combined with green laser in the treatment of macular edema due to ischemic central retinal vein occlusion is more effective in improving visual acuity than that in the treatment of ischemic central retinal vein occlusion in a short time. Promote the absorption of macular edema.
【學(xué)位授予單位】：中國醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R774.5

【參考文獻(xiàn)】

相關(guān)期刊論文 前5條

1 徐哲;劉誼;;關(guān)于放射狀視神經(jīng)切開術(shù)治療視網(wǎng)膜中央靜脈阻塞的爭議[J];國際眼科雜志;2006年02期

2 李貞;倪衛(wèi)杰;;視網(wǎng)膜新生血管生物藥物治療研究進(jìn)展[J];國際眼科雜志;2007年04期

3 李靈;席新華;;Avastin在眼科中的應(yīng)用[J];國際眼科雜志;2008年03期

4 于同利;畢宏生;;Avastin在眼科應(yīng)用的研究進(jìn)展[J];國際眼科雜志;2008年04期

5 盧寧,李志輝;視網(wǎng)膜靜脈阻塞治療新方法的實驗和臨床研究[J];國外醫(yī)學(xué).眼科學(xué)分冊;2001年02期

，

本文編號：2072574