本文選題：阻塞性睡眠呼吸暫停低通氣綜合征 + 骨質(zhì)疏松　； 參考：《山西醫(yī)科大學(xué)》2013年碩士論文

【摘要】：目的：觀察阻塞性睡眠呼吸暫停低通氣綜合征（Obstructive Sleep apnea-hypopneaSyndrome, OSAS)患者以及骨質(zhì)疏松患者血清中6-膠原特殊序列（6-Crosslaps，旦-cTX)與總1型膠原氨基端延長肽（Total Procollagen Type1Intact N-terminalPropeptide, total P1NP)濃度變化，探討3-Crosslaps與total P1NP在OSAS引起骨代謝紊亂中的作用及其臨床意義。 方法：為排除女性雌激素水平對骨代謝的影響，本研宄選取2012年8月至2013年3月期間與我院就診的男性作為受試者。選取經(jīng)我院體檢中心檢查后的健康、單純肥胖男性14例作為對照組；同時(shí)選取經(jīng)我院睡眠監(jiān)測中心經(jīng)多導(dǎo)睡眠監(jiān)測(Polysomnography, PSG)確診為OSAS的男性患者44例，并按睡眠呼吸紊亂指數(shù)(Apnea-hypopnea index，AHI)、夜間最低血氧飽和度(minimum blood oxygensaturation，SaChmiJ為依據(jù)，分為輕度組16人，中度組14人，重度組14人；選取我院內(nèi)分泌及骨科診斷為骨質(zhì)疏松的男性患者14例。所有受試者均記錄姓名、年齡、身高、體重、胸圍、腰圍、糖尿病、腎臟疾病、內(nèi)分泌疾病、冠心病、高血壓等家族史，同時(shí)經(jīng)過7個(gè)小時(shí)以上時(shí)間的多導(dǎo)睡眠監(jiān)測，，得到呼吸紊亂指數(shù)、夜間最低血氧飽和度等相關(guān)指標(biāo)，并于清晨抽取空腹外周靜脈血，在我院化驗(yàn)室采用電化學(xué)發(fā)光法測定0-Crosslaps與total P1NP血清濃度，同時(shí)在放射科采用放射線吸收法測定腰椎骨密度（bone mineral density，BMD)。 結(jié)果： 1. OSAS輕度組、中度組、重度組、單純肥胖組受試者的e-Crosslaps血清濃度分別為（0.563mg/ml、0.594mg/ml、0.665mg/ml、0.45mg/ml)，均低于單純骨質(zhì)疏松組（0.75mg/ml)，差異有統(tǒng)計(jì)學(xué)意義（P0.05)，且OSAS輕度、中度、重度組之間差異有統(tǒng)計(jì)學(xué)意義（P0.05); 2. OSAS輕度組、中度組、重度組、單純肥胖組受試者的totalP1NP血清濃度分別為（50.03ng/ml、54.11ng/ml、62.97ng/ml、38.17ng/ml)，均低于單純骨質(zhì)疏松組（66.05ng/ml)，差異有統(tǒng)計(jì)學(xué)意義（P0.05)，且OSAS輕度、中度、重度組之間差異有統(tǒng)計(jì)學(xué)意義（P0.05); 3. OSAS患者的e-Crosslaps、total P1NP血清濃度與AHI呈正相關(guān)，相關(guān)指數(shù)分別為（0.402，0.479，P0.05)，與Sa02mm呈負(fù)相關(guān)，相關(guān)指數(shù)分別為（-0.349，-0.303，P0.05)o 4. OSAS的嚴(yán)重程度與AHI、^-Crosslaps total P1NP呈正相關(guān)，相關(guān)指數(shù)分別為(0.942、0.351、0.365，P0.05)，與Sa02mm呈負(fù)相關(guān)，相關(guān)指數(shù)為（-0.792，P0.05)o 結(jié)論： 1. OSAS患者的-Crosslaps血清濃度較單純肥胖者升高，且升高水平與AHI、S a02min相關(guān)； 2. OSAS患者的total P1NP血清濃度較單純肥胖者升高，且升高水平與AHI、S a02min相關(guān)； 3.旦-Crosslaps與total P1NP血清濃度可作為OSAS患者評估骨代謝的指標(biāo)o
[Abstract]:Objective: To observe the concentration changes of 6- collagen specific sequence (6-Crosslaps, denier -cTX) in patients with obstructive sleep apnea hypopnea syndrome (Obstructive Sleep apnea-hypopneaSyndrome, OSAS) and the total type 1 collagen amino end lengthening peptide (Total Procollagen Type1Intact N-terminalPropeptide, total). Objective to investigate the role and clinical significance of 3-Crosslaps and total P1NP in OSAS induced bone metabolism disorders.
Methods: to exclude the effect of female estrogen level on bone metabolism, we selected men who visited our hospital from August 2012 to March 2013 as subjects. 14 cases of simple obese men were selected as the control group, and the sleep monitoring center of our hospital was monitored by polysomnography (Poly Somnography, PSG) 44 male patients diagnosed as OSAS, and according to the sleep respiratory disturbance index (Apnea-hypopnea index, AHI), the lowest nocturnal oxygen saturation (minimum blood oxygensaturation, SaChmiJ as the basis, divided into mild group 16 people, moderate group 14, severe group 14 people), selected our hospital Endocrinology and department of orthopedics diagnosis of osteoporosis male 14 patients. All the subjects recorded the family history of name, age, height, weight, chest circumference, waist circumference, diabetes, kidney disease, endocrine disease, coronary heart disease, hypertension and other family history, and after 7 hours of polysomnography, the index of respiratory disorder, the lowest night blood oxygen saturation and other related indexes were obtained, and an empty stomach was taken in the morning. The serum concentration of 0-Crosslaps and total P1NP was measured by electrochemiluminescence (ECL) in the laboratory in our hospital, and the bone mineral density (BMD) was measured by radioimmunoassay in the radiology department.
Result錛

本文編號：2006271