本文選題：糖尿病視網(wǎng)膜病變 + 視網(wǎng)膜中央動脈�。� 參考：《大連醫(yī)科大學(xué)》2010年碩士論文

【摘要】： 目的：通過研究糖尿病視網(wǎng)膜病變不同時期視網(wǎng)膜中央動脈血流動力學(xué)變化,為糖尿病視網(wǎng)膜病變的診斷及治療監(jiān)測及預(yù)后評估提供檢測依據(jù)。 方法：利用彩色多普勒超聲診斷儀(Color Doppler Imaging, CDI)測定62例(105眼)糖尿病視網(wǎng)膜病變(diabetic rctinopathy,DR)患者及20例正常對照組球后視網(wǎng)膜中央動脈(central retinal artery, CRA)血流狀態(tài),檢測指標包括視網(wǎng)膜中央動脈(CRA)的最大收縮期血流速度(peak systolic velocity, PSV)、舒張末期血流速度(end diastolic velocity,EDV)、平均血流速度(mean velocity,Vm)、搏動指數(shù)(pulsatility index,PI)和阻力指數(shù)(resistant index,RI)。分組如下：①對照組(normal control, NC選取健康人20例(40眼)作為對照。②糖尿病組依據(jù)最新國際分期接糖尿病視網(wǎng)膜病變的嚴重程度,分為三組研究組,其中包括糖尿病無視網(wǎng)膜病變(nondiabetic retinopathy. NDR)36眼,糖尿病視網(wǎng)膜病變非增殖期(nonproliferative diabetic retinopathy, NPDR) 34眼,糖尿病視網(wǎng)膜病變增殖期(proliferative diabetic retinopathy, PDR)35眼。各組之間年齡、性別差異無統(tǒng)計學(xué)意義(P0.05),采用成組t檢驗統(tǒng)計學(xué)方法對上述檢測指標進行各組之間分析比較 結(jié)果：結(jié)果顯示①糖尿病各組CRA的PSV、EDV和Vm均較正常對照組(NC組)減低(P0.05),RI和PI較正常對照組增高(P0.05)。②NPDR組和PDR組患者CRA的PSV、EDV及Vm較NDR組降低而RI和PI則增高(P0.05)。③NPDR與PDR之聞各參數(shù)差異無統(tǒng)計學(xué)意義(P0.05)。 結(jié)論：通過CDI對2型DM患者球后視網(wǎng)膜中央動脈血流動力學(xué)變化的動態(tài)檢測，對DR的早期診斷、治療監(jiān)測及預(yù)后評估有一定臨床應(yīng)用價值。
[Abstract]:Objective: to provide the basis for the diagnosis and treatment monitoring and prognosis evaluation of diabetic retinopathy by studying the hemodynamic changes of central retinal artery in different stages of diabetic retinopathy.
Methods: the blood flow status of the central retinal artery (central retinal artery, CRA) in 62 patients (105 eyes) with diabetic retinopathy (diabetic rctinopathy, DR) and 20 normal controls was measured by Color Doppler Imaging (CDI). The measurement index included the maximum contraction of the central retinal artery (CRA). Peak systolic velocity (PSV), end diastolic blood velocity (end diastolic velocity, EDV), average velocity of blood flow (mean velocity, Vm), pulsatile index, and resistance index were grouped as follows: 20 healthy persons (40 eyes) were selected as control. According to the severity of the latest international stage of diabetic retinopathy, the urinary disease group was divided into three groups, including 36 eyes of diabetic retinopathy (nondiabetic retinopathy. NDR), 34 eyes of non proliferative diabetic retinopathy (nonproliferative diabetic retinopathy, NPDR), and diabetic retinopathy proliferation (prol). Iferative diabetic retinopathy, PDR) 35 eyes. There was no statistically significant difference in age and sex between each group (P0.05). A group of t test statistics were used to analyze and compare the above indexes.
Results: the results showed that the PSV, EDV and Vm of CRA in each group were lower than that of the normal control group (P0.05), and the RI and PI were higher than those of the normal control group (P0.05).
Conclusion: the dynamic changes of the hemodynamic changes of the central retinal artery in type 2 DM patients by CDI have some clinical value for the early diagnosis of DR, the monitoring of the treatment and the evaluation of the prognosis.
【學(xué)位授予單位】：大連醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R587.1;R774.1

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