本文選題：型糖尿病 + 糖尿病視網(wǎng)膜病變��； 參考：《眼科新進展》2014年06期

【摘要】：目的探討血清25羥維生素D3[25-(OH)D3]水平與2型糖尿病視網(wǎng)膜病變(diabetic retinopathy,DR)的關(guān)系。方法選取144例2型糖尿病患者,分為無DR組(NDR組)50例、非增生期DR組(NPDR組)48例和增生期DR組(PDR組)46例,并選取同期來本院體檢的46例健康者為對照組(NDM組)。對每位患者進行臨床資料收集及常規(guī)生化指標(biāo)檢測,采用電化學(xué)發(fā)光法檢測所有受試者血清25-(OH)D3水平。結(jié)果 NDR組患者血清25-(OH)D3濃度為(28.10±10.23)ng·mL-1,明顯低于NDM組的(31.59±9.12)ng·mL-1,NPDR組患者血清25-(OH)D3濃度為(25.18±10.56)ng·mL-1,明顯低于NDR組,而PDR組患者血清25-(OH)D3濃度為(22.29±10.82)ng·mL-1,又明顯低于NPDR組,差異均有統(tǒng)計學(xué)意義(均為P0.05)。Pearson相關(guān)分析顯示,血清25-(OH)D3水平與病程、HbA1C、血肌酐均呈統(tǒng)計學(xué)上的負(fù)相關(guān)(r=-0.16、-0.19、-0.22,均為P0.05)。結(jié)論 2型DR患者血清25-(OH)D3水平明顯降低,且與DR的嚴(yán)重程度存在關(guān)聯(lián)。
[Abstract]:Objective to investigate the relationship between serum 25 hydroxyvitamin D 3 [25-(OH)D3] and type 2 diabetic retinopathy. Methods 144 patients with type 2 diabetes were divided into three groups: NDR group (n = 50), NPDR group (n = 48) and PDR group (n = 46). The clinical data were collected and routine biochemical indexes were detected. The serum 25-(OH)D3 level was measured by electrochemiluminescence (ECL). Results the level of serum 25-(OH)D3 in NDR group was 28.10 鹵10.23)ng mL-1, which was significantly lower than that in NDM group (31.59 鹵9.12)ng mL-1), which was significantly lower than that in NDR group (25.18 鹵10.56)ng mL-1), while that in PDR group was 22.29 鹵10.82)ng mL-1, which was significantly lower than that in NPDR group. The difference was statistically significant (all P0.05).Pearson correlation analysis showed that the serum 25-(OH)D3 level was negatively correlated with HbA1Cand creatinine in all patients (P 0.05). Conclusion the serum 25-(OH)D3 level in patients with type 2 Dr was significantly decreased and correlated with the severity of Dr.
【作者單位】： 新鄉(xiāng)醫(yī)學(xué)院第三附屬醫(yī)院內(nèi)分泌科;新鄉(xiāng)醫(yī)學(xué)院免疫學(xué)教研室;
【分類號】：R587.2;R774.1

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本文編號：1867621