本文選題：型糖尿病 + 糖尿病視網(wǎng)膜病變　； 參考：《眼科新進(jìn)展》2014年06期

【摘要】：目的探討血清25羥維生素D3[25-(OH)D3]水平與2型糖尿病視網(wǎng)膜病變(diabetic retinopathy,DR)的關(guān)系。方法選取144例2型糖尿病患者,分為無(wú)DR組(NDR組)50例、非增生期DR組(NPDR組)48例和增生期DR組(PDR組)46例,并選取同期來(lái)本院體檢的46例健康者為對(duì)照組(NDM組)。對(duì)每位患者進(jìn)行臨床資料收集及常規(guī)生化指標(biāo)檢測(cè),采用電化學(xué)發(fā)光法檢測(cè)所有受試者血清25-(OH)D3水平。結(jié)果 NDR組患者血清25-(OH)D3濃度為(28.10±10.23)ng·mL-1,明顯低于NDM組的(31.59±9.12)ng·mL-1,NPDR組患者血清25-(OH)D3濃度為(25.18±10.56)ng·mL-1,明顯低于NDR組,而PDR組患者血清25-(OH)D3濃度為(22.29±10.82)ng·mL-1,又明顯低于NPDR組,差異均有統(tǒng)計(jì)學(xué)意義(均為P0.05)。Pearson相關(guān)分析顯示,血清25-(OH)D3水平與病程、HbA1C、血肌酐均呈統(tǒng)計(jì)學(xué)上的負(fù)相關(guān)(r=-0.16、-0.19、-0.22,均為P0.05)。結(jié)論 2型DR患者血清25-(OH)D3水平明顯降低,且與DR的嚴(yán)重程度存在關(guān)聯(lián)。
[Abstract]:Objective to investigate the relationship between serum 25 hydroxyvitamin D 3 [25-(OH)D3] and type 2 diabetic retinopathy. Methods 144 patients with type 2 diabetes were divided into three groups: NDR group (n = 50), NPDR group (n = 48) and PDR group (n = 46). The clinical data were collected and routine biochemical indexes were detected. The serum 25-(OH)D3 level was measured by electrochemiluminescence (ECL). Results the level of serum 25-(OH)D3 in NDR group was 28.10 鹵10.23)ng mL-1, which was significantly lower than that in NDM group (31.59 鹵9.12)ng mL-1), which was significantly lower than that in NDR group (25.18 鹵10.56)ng mL-1), while that in PDR group was 22.29 鹵10.82)ng mL-1, which was significantly lower than that in NPDR group. The difference was statistically significant (all P0.05).Pearson correlation analysis showed that the serum 25-(OH)D3 level was negatively correlated with HbA1Cand creatinine in all patients (P 0.05). Conclusion the serum 25-(OH)D3 level in patients with type 2 Dr was significantly decreased and correlated with the severity of Dr.
【作者單位】： 新鄉(xiāng)醫(yī)學(xué)院第三附屬醫(yī)院內(nèi)分泌科;新鄉(xiāng)醫(yī)學(xué)院免疫學(xué)教研室;
【分類號(hào)】：R587.2;R774.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 馮煥煥;艾明;江雙紅;梁雄姿;;糖尿病視網(wǎng)膜病患者外周血25羥基維生素D的測(cè)定及臨床意義[J];醫(yī)學(xué)研究雜志;2012年07期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 田濤;鄺國(guó)平;武正清;謝麗蓮;劉茹;彭婧利;;糖尿病視網(wǎng)膜病變合并視網(wǎng)膜靜脈阻塞的臨床分析[J];國(guó)際眼科雜志;2013年08期

2 曾敏;李彬彬;;妊娠期糖尿病視網(wǎng)膜病變臨床分析[J];國(guó)際眼科雜志;2013年10期

3 張建文;馬麗;馬鳳仙;;糖尿病視網(wǎng)膜病變發(fā)生發(fā)展的相關(guān)因素分析[J];國(guó)際眼科雜志;2013年11期

4 夏偉;王利;李蓬秋;張學(xué)軍;楊艷;楊毅;;應(yīng)用免散瞳眼底照相技術(shù)篩查糖尿病視網(wǎng)膜病變臨床分析[J];國(guó)際眼科雜志;2013年11期

5 郭勇;劉燕;張少波;;不同激光光凝術(shù)治療增殖期糖尿病性視網(wǎng)膜病變觀察[J];國(guó)際眼科雜志;2013年11期

6 Mvitu Muaka Moise;Longo-Mbenza Benjamin;Cibanda Yokobo Enoch;Longo Phemba Igor;;Mayombian ethnic,vegetables low intake,insulin treatment,diabetic nephropathy and severe diabetic retinopathy are determinants of blindness in diabetic Africans[J];International Journal of Ophthalmology(English Edition);2013年05期

7 段俊國(guó);羅向霞;許國(guó)旺;李響;;DR病情進(jìn)展與陽(yáng)虛病機(jī)關(guān)系的研究[J];西部中醫(yī)藥;2013年08期

8 原U，

本文編號(hào)：1867621