本文選題：光學相干斷層掃描 + 眼底熒光血管造影��； 參考：《眼科新進展》2014年07期

【摘要】：目的光學相干斷層掃描(optical coherence tomography,OCT)與眼底熒光血管造影(fundus fluorescein angiography,FFA)在糖尿病視網(wǎng)膜病變臨床前期的應用比較。方法以2型糖尿病病史10~15 a尚處于DR臨床前期的患者76例為研究對象進行OCT和FFA檢查,以及糖化血紅蛋白(glycosylated hemoglobins A1c,HbAlc)、空腹血糖(fasting blood-glucose,FBG)等檢測,記錄患者視盤周圍視網(wǎng)膜神經(jīng)纖維層(retinal nerve fiber layer,RNFL)的厚度變化和視網(wǎng)膜微血管的異常情況,結(jié)合HbAlc、FBG等檢測結(jié)果分析兩者的關系。結(jié)果 OCT或FFA檢查異常者共31例(占40.8%),其中19例兼有OCT檢查異常(RNFL變薄)和FFA檢查異常(出現(xiàn)異常熒光),10例僅表現(xiàn)為OCT檢查異常,2例僅表現(xiàn)為FFA檢查異常。OCT的陽性檢出率(29例,38.2%)高于FFA(21例,27.6%),差異有統(tǒng)計學意義(P≤0.05);OCT檢查陽性者29例HbAlc的檢測值(6.98±1.01)%高于檢查陰性者47例(6.52±0.86)%,差異也有統(tǒng)計學意義(P0.05);OCT檢查陽性者FBG檢測值(7.51±0.81)mmol·L-1與陰性者(7.38±0.72)mmol·L-1比較差異無統(tǒng)計學意義(P0.05)。結(jié)論 OCT和FFA是發(fā)現(xiàn)早期DR的有效檢查手段,兩者相比較OCT更為敏感,而且為無創(chuàng)性檢查,更適用于DR篩查和隨訪復檢。
[Abstract]:Objective to compare the application of optical coherence tomography (coherence) and fundus fluorescein angiography (FFA) in diabetic retinopathy. Methods 76 patients with type 2 diabetes mellitus who were still in the pre-clinical stage of Dr for 10 ~ 15 years were examined by OCT and FFA, and the glycosylated hemoglobins A _ 1C ~ (1) HbAlcn and fasting blood glucose (FBG) were measured. The thickness of retinal nerve fiber layer (nerve fiber layerus) and the abnormality of retinal microvessel were recorded, and the relationship between them was analyzed. Results there were 31 cases with abnormal OCT or FFA examination (40.8%), 19 cases with abnormal OCT examination and 10 cases with abnormal FFA examination (10 cases with abnormal OCT and 2 cases with abnormal FFA. Oct). The detection rate of sex was higher in 29 cases (38.2%) than in FFA(21 cases (27.6T). The difference was statistically significant (P 鈮，

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