本文選題：增殖性糖尿病視網(wǎng)膜病變　切入點(diǎn)：玻璃體　出處：《中國(guó)醫(yī)科大學(xué)》2010年碩士論文

【摘要】： 目的 檢測(cè)增殖性糖尿病視網(wǎng)膜病變(proliferative diabetic retinopathy, PDR)患者玻璃體中單核細(xì)胞趨化蛋白-1(monocyte chemotactic protein-1, MCP-1)的表達(dá)水平,探討其在DR疾病發(fā)生發(fā)展過程中所發(fā)揮的作用。 方法 應(yīng)用酶聯(lián)免疫吸附法(enzyme-linked immunosorbent assay,ELISA)檢測(cè)22例PDR患者(實(shí)驗(yàn)組)玻璃體中MCP-1的含量,并與15例視網(wǎng)膜脫離患者(疾病對(duì)照組)及2例正常人眼(正常對(duì)照組)玻璃體中MCP-1的含量進(jìn)行比較。 結(jié)果 實(shí)驗(yàn)組MCP-1的含量為(1316.85±286.402)μg/ml,高于疾病對(duì)照組(652.15±410.375)μg/ml以及正常對(duì)照組(182.60±77.631)μg/ml。差異有統(tǒng)計(jì)學(xué)意義(p0.01)。 結(jié)論 MCP-1在PDR患者玻璃體中存在高表達(dá),提示MCP-1可能參與了糖尿病患者DR的發(fā)生發(fā)展過程,可能為疾病發(fā)生的啟動(dòng)環(huán)節(jié)或啟動(dòng)環(huán)節(jié)之一并貫穿始終。
[Abstract]:objective
Objective to detect the expression level of monocyte chemoattractant protein -1 (monocyte chemotactic protein-1, MCP-1) in vitreous body of patients with proliferative diabetic retinopathy (PDR) and to explore its role in the occurrence and development of DR disease.
Method
The application of enzyme linked immunosorbent assay (enzyme-linked immunosorbent, assay, ELISA) were detected in 22 patients with PDR (experimental group) content of vitreous body of MCP-1, and 15 cases of patients with retinal detachment (disease control group) and 2 cases of normal people (normal control group) were compared with the amount of MCP-1 in the vitreous body.
Result
The content of MCP-1 in the experimental group was (1316.85 + 286.402) g/ml, which was higher than that in the disease control group (652.15 + 410.375) g/ml and the normal control group (182.60 + 77.631) g/ml., the difference was statistically significant (P0.01).
conclusion
MCP-1 has high expression in vitreous body of PDR patients, suggesting that MCP-1 may be involved in the occurrence and development of DR in diabetic patients, and may be the starting link or starting link of disease.

【學(xué)位授予單位】：中國(guó)醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類號(hào)】：R774.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 崔蕾;盧海;;眼內(nèi)液中PEDF、VEGF含量變化對(duì)糖尿病視網(wǎng)膜病變的意義(英文)[J];國(guó)際眼科雜志;2007年01期

2 陳慷;胡世興;杜連心;林少春;羅琳;;單核細(xì)胞趨化蛋白-1在實(shí)驗(yàn)性糖尿病大鼠視網(wǎng)膜中的表達(dá)及意義[J];眼科新進(jìn)展;2007年04期

，

本文編號(hào)：1670961