本文選題：AKT　切入點：HK　出處：《中國耳鼻咽喉顱底外科雜志》2017年03期 　論文類型：期刊論文

【摘要】：目的探討絲氨酸/蘇氨酸蛋白激酶AKT(the serine/threonine kinase,also known as protein kinase B,PKB)、己糖激酶2(hexokinase 2,HK2)在喉鱗狀細胞癌組織及癌旁組織中的表達,分析其與喉癌發(fā)病諸病理因素間的相互關(guān)系。方法采用免疫組化Streptavidian-perosidase(SP)法檢測30例喉癌患者的癌組織中AKT和HK2蛋白的表達情況,同期選取其癌旁組織作為對照。結(jié)果 AKT、HK2蛋白在喉癌組織中高表達,與腫瘤的分化程度和有無淋巴結(jié)轉(zhuǎn)移密切相關(guān),差異具有統(tǒng)計學(xué)意義(P0.05);AKT、HK2蛋白的陽性表達與患者的年齡、腫瘤發(fā)生部位以及臨床分期無關(guān)(P0.05);喉鱗癌組織中AKT與HK2的表達呈正相關(guān)(r=0.424,P=0.019)。結(jié)論喉鱗癌組織中AKT、HK2蛋白高表達與腫瘤的侵襲和轉(zhuǎn)移密切相關(guān),可提示預(yù)后不良。
[Abstract]:Objective to investigate the expression of serine / threonine protein kinase (AKT(the serine/threonine kinase) in laryngeal squamous cell carcinoma (LSCC) and adjacent tissues. Methods Immunohistochemical method was used to detect the expression of AKT and HK2 protein in 30 patients with laryngeal carcinoma. Results the overexpression of AKTU HK2 protein in laryngeal carcinoma tissues was closely related to the degree of tumor differentiation and lymph node metastasis. The difference was statistically significant between the positive expression of AKT HK2 protein and the age of the patients. The expression of AKT and HK2 in laryngeal squamous cell carcinoma was positively correlated with the expression of HK2. Conclusion the overexpression of AKTT HK2 protein in laryngeal squamous cell carcinoma is closely related to the invasion and metastasis of the tumor, which may indicate that the prognosis is not good.
【作者單位】： 河北醫(yī)科大學(xué)第二醫(yī)院耳鼻咽喉科;
【基金】：河北省自然科學(xué)基金(2016206535) 河北省醫(yī)學(xué)科學(xué)研究重點課題計劃(20160120)
【分類號】：R739.65

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