本文選題：內(nèi)翻性乳頭狀瘤　切入點(diǎn)：人乳頭狀瘤病毒　出處：《寧夏醫(yī)科大學(xué)》2010年碩士論文　論文類型：學(xué)位論文

【摘要】：目的探討人乳頭狀瘤病毒(Human Papillomavirus,HPV)在鼻內(nèi)翻性乳頭狀瘤(Nasal Inverted Papilloma,NIP)中感染亞型的分布及其在病變發(fā)生、發(fā)展中的作用。 方法取101例NIP石蠟包埋組織標(biāo)本采用核酸分子快速導(dǎo)流雜交基因芯片分型技術(shù)(HybriMax)對21種HPV亞型同步進(jìn)行檢測和病毒分型,并以24例健康志愿者鼻腔黏膜組織為對照。 結(jié)果NIP石蠟標(biāo)本HPV總陽性率64.36%(65/101)。對照組HPV均為陰性(0/24)。兩組比較差異有統(tǒng)計(jì)學(xué)意義(χ2=32.178,P0.05)。單純NIP組、伴不典型增生NIP組、癌變組HPV陽性率分別為59.74%(46/77)、81.82%(18/22)、50%(1/2)。單純NIP組與伴不典型增生NIP組的HPV感染率比較差異無統(tǒng)計(jì)學(xué)意義(χ2=3.649,P =0.056)。單純NIP組與伴不典型增生NIP組的HPV高危亞型、低危亞型的構(gòu)成比差異有統(tǒng)計(jì)學(xué)意義(χ2=10.412,P0.05)。參照Krouse分期體系,101例NIP分為四組,即KrouseI-IV期,四組HPV陽性率分別為45.45%(10/22)、62.50%(10/56)、89.47%(17/19)、75.00%(3/4),四組不同臨床分期的NIP中的HPV感染率差異有統(tǒng)計(jì)學(xué)意義(χ2=8.349,P0.05)。 結(jié)論NIP的發(fā)病與HPV感染密切相關(guān),HPV11、58、16、44型可能是與國人鼻內(nèi)翻性乳頭狀瘤發(fā)生發(fā)展相關(guān)的主要亞型。HPV高危亞型或多重亞型混合感染能促使NIP向不典型增生發(fā)展,HPV感染可能使NIP病變范圍擴(kuò)大。明確NIP中HPV亞型的分布情況對腫瘤臨床行為的預(yù)測有一定的指導(dǎo)意義。
[Abstract]:Objective to investigate the distribution of human papillomavirus (HPV) infection subtype in nasal inverted papillomavirus (nipp) and its role in the pathogenesis and development of human papillomavirus (HPV). Methods Twenty-one HPV subtypes and virus typing were detected in 101 NIP paraffin-embedded tissue samples by hybridization hybridization gene typing technique and 24 healthy volunteers were used as control. Results the total positive rate of HPV in paraffin wax specimens of NIP was 64.36% and 65 / 101% respectively. The HPV of control group was negative 0 / 24%. There was a significant difference between the two groups (蠂 2 + 32.178% P 0.05). In simple NIP group, NIP group with atypical hyperplasia, there was a significant difference between the two groups. The positive rates of HPV in cancer group were 59.74 / 46 / 77 / 81.82 and 18 / 22 / 50 / 2 respectively. There was no significant difference in HPV infection rate between simple NIP group and NIP group with atypical hyperplasia (蠂 ~ (2) 3.649) P ~ (0.056). The high risk subtypes of HPV in simple NIP group and NIP group with atypical hyperplasia were not significantly different. According to the Krouse staging system, 101 cases of NIP were divided into four groups: KrouseI-IV stage. The positive rates of HPV in the four groups were 45.4510 / 10 / 22 / 62.50 / 10 / 56 / 10.47 / 1975.00 / 3 / 4, respectively (蠂 ~ 28.349 / P 0.05), and there was a significant difference in HPV infection rate among the four groups (蠂 ~ 28.349 / P 0.05). Conclusion the pathogenesis of NIP is closely related to the infection of HPV. HPV1158 / 1644 may be the main subtype associated with the occurrence and development of Chinese nasal inverted papilloma. High risk subtype or multiple subtypes of HPVinfection may promote the development of NIP towards atypical hyperplasia. The distribution of HPV subtypes in NIP may be helpful to predict the clinical behavior of NIP.
【學(xué)位授予單位】：寧夏醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R739.62

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 劉翠苓,王笑健,宮恩聰,周玉英;鼻內(nèi)翻性乳頭狀瘤與人類乳頭狀瘤病毒的關(guān)系[J];北京醫(yī)科大學(xué)學(xué)報(bào);1998年03期

2 包永新,馬秀嵐;HPV16和p53蛋白在鼻腔鼻竇腫瘤組織中的作用[J];中國醫(yī)師雜志;2005年01期

3 楊景,柳鳳軒;鼻及副鼻竇內(nèi)翻性乳頭狀瘤臨床病理及其與預(yù)后的關(guān)系[J];第三軍醫(yī)大學(xué)學(xué)報(bào);2000年07期

4 張盛忠,徐愛真,王琪;鼻腔及鼻竇乳頭狀瘤[J];中國耳鼻咽喉頭頸外科;2005年03期

5 李志剛,周曉軍,孔慶兗,易龍,孟奎;乳腺浸潤性導(dǎo)管癌染色體8p22、11p15、17p13區(qū)雜合性缺失的研究[J];醫(yī)學(xué)研究生學(xué)報(bào);2004年03期

6 余洪猛,張重華,臧朝平,王德輝,鄭春泉;鼻內(nèi)窺鏡在鼻內(nèi)翻性乳頭狀瘤手術(shù)中的價(jià)值[J];臨床耳鼻咽喉科雜志;2002年05期

7 關(guān)亞峰;臧朝平;張重華;;人乳頭狀瘤病毒57感染與鼻內(nèi)翻性乳頭狀瘤發(fā)生的相關(guān)性[J];臨床耳鼻咽喉科雜志;2006年20期

8 林勤,易自翔,楊勁松,林昶,周愛東,林有輝;不同類型鼻內(nèi)乳頭狀瘤與HPV感染的關(guān)系[J];山東醫(yī)大基礎(chǔ)醫(yī)學(xué)院學(xué)報(bào);2002年01期

9 何國琳;方芳;;人乳頭瘤病毒疫苗的研究進(jìn)展[J];實(shí)用婦產(chǎn)科雜志;2008年03期

10 王鑫;萬艷平;;人乳頭瘤病毒E6蛋白在細(xì)胞凋亡中的作用[J];微生物與感染;2006年01期

，

本文編號：1601843