本文選題：硬性透氣性角膜接觸鏡　切入點(diǎn)：表面改性　出處：《華南理工大學(xué)》2010年碩士論文　論文類型：學(xué)位論文

【摘要】： 氟硅氧烷丙烯酸酯(fluorosilicone acrylate,FSA)是一種硬性透氣性角膜接觸鏡(rigid gas permeable contact lens,RGPCL)材料,它的特點(diǎn)是透氣性能好,能夠應(yīng)用于延緩青少年近視進(jìn)一步發(fā)展方面。但是,其初戴舒適性差,適應(yīng)時(shí)間稍長(zhǎng),由于含氟、硅等元素,親水性差,淚液難以鋪展開,易引起淚液中蛋白質(zhì)的沉積。為提高其親水性,降低蛋白質(zhì)在材料表面的沉積,提高潤(rùn)濕性、延長(zhǎng)配戴時(shí)間及改善配戴舒適度等,本論文通過(guò)等離子體表面處理和等離子體表面接枝聚合兩種方法對(duì)FSA RGP角膜接觸鏡材料進(jìn)行了表面改性,并對(duì)改性前后材料的表面結(jié)構(gòu)和性能進(jìn)行了表征,包括X射線光電子能譜(XPS)、表面形態(tài)觀察及親水性、折射率、時(shí)效性、蛋白質(zhì)沉淀等測(cè)試。 采用等離子體表面處理方法分別在不同等離子體處理時(shí)間和不同放電功率條件下對(duì)FSA RGP角膜接觸鏡材料進(jìn)行氨等離子體處理及氧等離子體處理。XPS結(jié)果表明,用氨/氧等離子體處理接觸鏡表面的過(guò)程中,存在鍵的斷裂及親水性基團(tuán)的形成,從而使其表面的親水性增強(qiáng);經(jīng)過(guò)氨/氧等離子體處理后接觸鏡表面的接觸角明顯降低,表面能增加,親水性得到明顯改善;改性前后接觸鏡的表面相對(duì)平整,折射率沒(méi)有明顯變化;等離子體處理效果具有時(shí)效性,經(jīng)氨/氧等離子體處理接觸鏡的表面接觸角隨著其放置時(shí)間的延長(zhǎng)逐漸增大,其親水性明顯降低。 采用氨/氧等離子體表面接枝聚合方法在一定的等離子體處理時(shí)間和放電功率條件下將具有高親水性、良好生物相容性及防止蛋白質(zhì)吸附性質(zhì)的仿生大分子2-甲基丙烯酰氧乙基磷酸膽堿(MPC)接枝到FSA RGP角膜接觸鏡材料表面。XPS結(jié)果表明,通過(guò)氨/氧等離子體表面接枝方法將MPC成功地接枝到了接觸鏡的表面;經(jīng)改性后接觸鏡表面的接觸角明顯降低,表面能增加,親水性得到明顯改善;改性前后接觸鏡的表面相對(duì)平整,折射率沒(méi)有明顯變化;蛋白質(zhì)沉淀的研究結(jié)果表明,經(jīng)改性后的接觸鏡降低了蛋白質(zhì)在鏡片上的沉積。 采用氨/氧等離子體表面接枝聚合方法在一定的等離子體處理時(shí)間和放電功率條件下將具有良好親水性、生物相容性及防止蛋白質(zhì)吸附性質(zhì)的聚乙二醇二丙烯酸酯(PEGDA)接枝到FSA RGP角膜接觸鏡材料表面。XPS結(jié)果表明,通過(guò)氨/氧等離子體表面接枝方法將PEGDA接枝到了FSA RGP角膜接觸鏡的表面;經(jīng)改性后接觸鏡表面的接觸角明顯降低,表面能增加,親水性得到明顯改善;改性前后接觸鏡的折射率沒(méi)有明顯變化;蛋白質(zhì)沉淀的研究結(jié)果表明,經(jīng)改性后的接觸鏡降低了蛋白質(zhì)在鏡片上的沉積,接枝PEGDA10000的鏡片比接枝PEGDA4000的效果更好。
[Abstract]:Fluorosilicone acrylate (fluorosilicone acrylate FSA) is a kind of rigid gas permeable contact lens (rigid gas permeable contact lens, RGPCL) material, it is characteristic of good air permeability, can be applied to delay the further development of juvenile myopia. However, the primary wear comfort, fit for a long time, because of containing fluorine, silicon and other elements, poor hydrophilicity, tear is difficult to spread, easy to cause the deposition of tear proteins. In order to improve the hydrophilicity, reduce the protein deposition on the material surface, improve wettability, extended wear time and improve the wearing comfort, the paper surface processing by plasma polymerization and plasma surface grafting two methods the FSA RGP corneal contact lens material was surface modified and modified the surface of the material structure and properties were characterized, including the X ray photoelectron spectroscopy (XPS), the surface morphology of view Detection of hydrophilicity, refractive index, aging, protein precipitation and so on.
The plasma surface treatment method in different plasma treatment time and discharge power under the condition of different FSA RGP contact lens material ammonia plasma treatment and oxygen plasma treatment.XPS results show that the process of contact lens surface with ammonia / oxygen plasma treatment, the formation of existing bond cleavage and hydrophilic groups, so that the hydrophilic the enhancement of the surface; after ammonia / oxygen plasma treatment after contact lens surface contact angle decreased, the surface energy increases, hydrophilicity was improved obviously; surface modification and contact lens of smooth refractive index did not change significantly; the plasma treatment effect with the timeliness, the ammonia / oxygen plasma treatment on the surface of contact contact lens angle with the extension of storage time increased, the hydrophilicity decreased obviously.
The ammonia / oxygen plasma surface grafting polymerization method in a plasma processing time and discharge power under the condition of high hydrophilicity, biocompatibility and adsorption properties to prevent protein deposition 2- methacryloyloxyethyl phosphorylcholine (MPC) grafted to the good biological FSA RGP corneal contact lens material surface.XPS results show that by the ammonia / oxygen plasma grafting of MPC was successfully grafted onto the surface of contact lens; modified contact lens surface contact angle decreased, the surface energy increases, hydrophilicity was improved obviously; modified surface before and after the contact lens is relatively smooth, the refractive index did not change significantly; the research results show that protein precipitation after the change, the contact lens after reduced protein deposition on the lens.
The ammonia / oxygen plasma surface grafting polymerization method in a plasma processing time and discharge power conditions will have good hydrophilicity, biocompatibility and adsorption properties of polyethylene glycol to prevent protein two (PEGDA) acrylate grafted onto FSA RGP corneal contact lens surface.XPS results show that PEGDA grafted onto FSA RGP contact mirror by plasma surface grafting method of oxygen / ammonia; after modification of contact lens surface contact angle decreased, the surface energy increases, the hydrophilicity was improved; change before and after the contact lens refraction rate did not change significantly; protein deposition study results show that the modified contact lens after reducing the deposition of protein in the lens, the lens is better than the PEGDA10000 graft graft PEGDA4000 effect.

【學(xué)位授予單位】：華南理工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類號(hào)】：R778

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 周浩;柯賢文;程紅炬;;低溫等離子體技術(shù)及其在塑料包裝中的應(yīng)用[J];包裝工程;2008年03期

2 周美麗;;低溫等離子體技術(shù)在印刷與包裝上的應(yīng)用[J];包裝世界;2008年06期

3 任煜;邱夷平;;低溫等離子體對(duì)高聚物材料表面改性處理時(shí)效性的研究進(jìn)展[J];材料導(dǎo)報(bào);2007年01期

4 黎新明;崔英德;尹國(guó)強(qiáng);廖列文;賈振宇;毛淑才;林海琳;;基于角膜接觸鏡的眼藥緩釋水凝膠材料研究進(jìn)展[J];材料導(dǎo)報(bào);2008年02期

5 湯琦;于俊榮;陳蕾;諸靜;胡祖明;;水凝膠角膜接觸鏡材料研究進(jìn)展[J];材料導(dǎo)報(bào);2009年07期

6 謝漢平,竇遠(yuǎn)松,汪輝,任茜;親水性軟性角膜接觸鏡治療角膜病的療效分析[J];第三軍醫(yī)大學(xué)學(xué)報(bào);2004年08期

7 張麗華;吳迪;陳亞芍;李雪嬌;趙寶明;黃長(zhǎng)征;;PMMA人工晶狀體表面的CF_4/O_2等離子體修飾[J];高等學(xué)�；瘜W(xué)學(xué)報(bào);2008年09期

8 熊成東,王亞輝,袁明龍,鄧先模;聚乙二醇衍生物的合成研究進(jìn)展[J];高分子通報(bào);2000年01期

9 姜忠義,許松偉,高蓉;生物分子化學(xué)修飾用聚乙二醇衍生物的合成及應(yīng)用[J];高分子通報(bào);2002年01期

10 肖志剛;陶利娟;郭燕;王平;;硬性透氧性角膜接觸鏡對(duì)兒童高度近視的矯治效果[J];國(guó)際眼科雜志;2009年05期

相關(guān)博士學(xué)位論文 前1條

1 蔡立彬;有機(jī)硅改性水凝膠角膜接觸鏡材料的研究[D];西北工業(yè)大學(xué);2006年

相關(guān)碩士學(xué)位論文 前2條

1 崔亦華;NVP三元共聚物水凝膠角膜接觸鏡材料的研究[D];廣東工業(yè)大學(xué);2002年

2 徐彪;低溫等離子體技術(shù)在高分子材料表面改性中的應(yīng)用研究[D];南京理工大學(xué);2008年

，

本文編號(hào)：1575764