本文關(guān)鍵詞： 氧化應(yīng)激 過氧化氫酶 吸煙 癌 鱗狀細(xì)胞　出處：《臨床耳鼻咽喉頭頸外科雜志》2015年15期 　論文類型：期刊論文

【摘要】：目的:探討氧化應(yīng)激在吸煙相關(guān)喉鱗狀細(xì)胞癌發(fā)生發(fā)展中的影響,以及過氧化氫酶(CAT)對(duì)吸煙相關(guān)喉鱗狀細(xì)胞癌的臨床診斷意義。方法:收集吸煙人群119例,其中吸煙相關(guān)喉鱗狀細(xì)胞癌組68例、非喉鱗狀細(xì)胞癌人群(對(duì)照組)51例,比較2組血漿和癌組織的CAT、丙二醛(MDA)、超氧化物歧化酶(SOD)、還原型谷胱甘肽(GSH)、一氧化氮(NO)水平,分析氧化應(yīng)激指標(biāo)與吸煙相關(guān)喉鱗狀細(xì)胞癌及其嚴(yán)重程度的關(guān)系。結(jié)果:1與對(duì)照組相比,喉鱗狀細(xì)胞癌組的吸煙密度、吸煙支數(shù)、CAT、MDA、GSH顯著升高(均P0.01);而SOD、NO明顯下降(均P0.01)。2隨著喉鱗狀細(xì)胞癌組織分化程度越低,血清CAT越高(P0.01),癌組織勻漿的CAT、MDA、GSH也越高(均P0.01),而血清NO則越低(P0.01),癌組織勻漿的SOD、NO越低(均P0.01);喉鱗狀細(xì)胞癌患者臨床分期越高,血清和癌組織的CAT、癌組織的GSH越高(均P0.01),而癌組織NO越低(P0.01)。3血清CAT、MDA為吸煙相關(guān)喉鱗狀細(xì)胞癌發(fā)病的獨(dú)立危險(xiǎn)因素(OR=1.060,2.475;P0.01,P0.05)。結(jié)論:氧化應(yīng)激是吸煙人群發(fā)生喉鱗狀細(xì)胞癌的主要影響因素,CAT可作為吸煙相關(guān)喉鱗狀細(xì)胞癌的臨床診斷指標(biāo)。
[Abstract]:Objective: to investigate the effect of oxidative stress on the occurrence and development of smoking associated laryngeal squamous cell carcinoma (LSCC) and the clinical significance of catalase catalase (CAT) in the diagnosis of smoking-related laryngeal squamous cell carcinoma (LSCC). Methods: 119 cases of smoking were collected. The levels of CAT, malondialdehyde (MDA) MDAA, superoxide dismutase (SOD), glutathione glutathione (GSH), nitric oxide (no) in plasma and cancer tissues were compared in 68 patients with smoking associated laryngeal squamous cell carcinoma and 51 patients with non-laryngeal squamous cell carcinoma (control group, n = 51). The relationship between oxidative stress and smoking related laryngeal squamous cell carcinoma (LSCC) and its severity was analyzed. The number of cigarette smoking and the GSH of MDAA were significantly increased (all P 0.01), while the level of SODN decreased significantly (P 0.01 / 2) with the degree of differentiation of laryngeal squamous cell carcinoma (LSCC) decreased. The higher the serum CAT level was, the higher the level of CAT in cancer tissue homogenate was (P 0.01), and the lower the level of serum no was (P 0.01), the lower the level of CAT in cancer tissue homogenate was (P 0.01), the higher the clinical stage was in laryngeal squamous cell carcinoma (LSCC). In serum and cancer tissues, the GSH of cancer tissue was higher than that of cancer tissue (P 0.01), and the lower the no level in cancer tissue was, the lower the level of serum GSH was. The serum GSH was the independent risk factor of smoking related laryngeal squamous cell carcinoma. Conclusion: oxidative stress is an independent risk factor for smoking related laryngeal squamous cell carcinoma. Conclusion: oxidative stress is the occurrence of laryngeal squamous cell carcinoma in smokers. Cat can be used as a diagnostic marker for smoking-related laryngeal squamous cell carcinoma.
【作者單位】： 河北北方學(xué)院附屬第一醫(yī)院耳鼻咽喉頭頸外科;
【分類號(hào)】：R739.65

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本文編號(hào)：1529665