甲狀腺相關眼病眼眶CT定量測量及亞型分析
發(fā)布時間:2018-01-04 05:36
本文關鍵詞:甲狀腺相關眼病眼眶CT定量測量及亞型分析 出處:《第二軍醫(yī)大學》2013年碩士論文 論文類型:學位論文
更多相關文章: 甲狀腺相關眼病 眼外肌 眼眶CT TAO亞型
【摘要】:目的:甲狀腺相關眼病(TAO)主要累及眶脂肪和眼外肌,準確的眼眶影像學檢查對于TAO的診療非常重要。本文主要探討通過眼眶冠狀位CT圖像定量測量TAO患者眼外肌橫截面積的可行性,評價其臨床意義,并根據(jù)眼外肌情況討論TAO亞型的分類。 方法:回顧性病例觀察研究。本研究主要納入20例正常對照患者,42例TAO住院患者眼眶冠狀位CT平掃影像學資料,利用autoCAD軟件計算各眼外肌最粗處橫截面積。統(tǒng)計TAO患者各條眼外肌增粗情況,分析眼外肌總橫截面積與CAS評分、眼球突出度、眼壓、矯正視力的相關性,并且根據(jù)眼外肌總橫截面和眼球突出度,將TAO分為四種亞型:Ⅰ型:眶脂肪和眼外肌均不增粗;Ⅱ型:眶脂肪增多為主;Ⅲ型:眼外肌增粗為主;Ⅳ型:眶脂肪增多、眼外肌增粗。 結果: TAO組患者下直肌、外直肌、提上瞼肌上直肌復合體、內直肌及眼外肌總橫截面積均大于正常對照組,差異有統(tǒng)計學意義(p<0.001,p=0.033,,p<0.001,p<0.001,p<0.001)。下直肌、提上瞼肌上直肌復合體增粗最常見(分別為60.71%、58.33%),其次為內直肌(40.48%),外直肌增粗較為少見(25%),眼外肌總橫截面積增大(66.67%)。眼外肌總橫截面積與CAS評分成正相關(r=0.791,p<0.001),與矯正視力成負相關(r=-0.658,p<0.001),與眼壓成正相關(r=0.454,p=0.019),提上瞼肌上直肌復合體橫截面積與上瞼退縮程度成正相關(r=0.304,p=0.005)。根據(jù)眼外肌總橫截面積和眼球突出度,可將TAO分為4種亞型:Ⅰ型0例,眶脂肪和眼外肌均不增多;Ⅱ型9例(21.4%),眶脂肪增多為主;Ⅲ型10例(23.8%),眼外肌增粗為主;Ⅳ型23例(54.8%),眶脂肪和眼外肌均增多。Ⅱ型患者的年齡小于Ⅲ型和Ⅳ型TAO,差異有統(tǒng)計學意義(p<0.001)。Ⅱ型患者CAS評分均小于4分,處于非活動期,視力一般不受影響,多有131I治療史,而Ⅲ型和Ⅳ型患者CAS評分明顯高于Ⅱ型患者,矯正視力低于Ⅱ型患者,容易發(fā)展為視力威脅型TAO。 結論: TAO患者眼眶CT冠狀位平掃定量測量眼外肌橫截面積,能夠準確反映各眼外肌增粗的情況,眼外肌總橫截面積的大小可用于評估TAO患者的活動性,并為區(qū)分TAO亞型提供了可靠依據(jù),在TAO亞型中,Ⅱ型患者以眶脂肪增多為主,多發(fā)生于年輕女性,有131I治療史,多雙眼發(fā)病,無復視,病情處于穩(wěn)定期;Ⅲ型和Ⅳ型患者以眼外肌增粗為主,有部分患者單眼發(fā)病,復視較明顯,病情較重。
[Abstract]:Objective: thyroid associated ophthalmopathy (TAO) is mainly involved in orbital adipose tissue and extraocular muscle and orbital image accurate examination is very important for the diagnosis and treatment of TAO. This paper mainly discusses the feasibility of extraocular orbital coronal CT image quantitative measurement of TAO in patients with muscle cross-sectional area, to evaluate its clinical significance, and according to the discussion of extraocular muscle the classification of subtype TAO.
Methods: a retrospective case study. This study included 20 cases of normal control patients, 42 cases of TAO orbital coronal CT scan imaging data, using autoCAD software to calculate the extraocular muscles at the thickest cross-sectional area. The statistical TAO patients with extraocular muscle enlargement of extraocular muscle total analysis the cross-sectional area of the CAS score, the degree of exophthalmos, intraocular pressure, visual acuity and correlation, according to the total cross section of extraocular muscle and exophthalmos, TAO is divided into four subtypes: type I: orbital fat and extraocular muscles were not thickened; type II: orbital fat; type III: extraocular muscle enlargement; type IV: orbital fat, extraocular muscle.
緇撴灉錛
本文編號:1377309
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