【摘要】：目的:探討不同劑量阿托伐他汀預(yù)處理對(duì)行經(jīng)皮冠狀動(dòng)脈介入治療(PCI)的非ST段抬高型急性冠脈綜合征(NSTEACS)患者的保護(hù)作用。方法:選取2014年1月-2016年4月某院收治的NSTE-ACS患者81例,按隨機(jī)數(shù)字表法分為高劑量組(40例)和低劑量組(41例)。高劑量組患者在PCI術(shù)前12～24 h給予阿托伐他汀鈣片80 mg,術(shù)前2 h再給予40 mg;低劑量組患者在PCI術(shù)前12～24 h給予阿托伐他汀鈣片10 mg。觀察兩組患者術(shù)后血流儲(chǔ)備分?jǐn)?shù)(FFR)、冠脈血流儲(chǔ)備分?jǐn)?shù)(CFR)和微循環(huán)阻力指數(shù)(IMR),比較兩組患者手術(shù)前后肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)和高敏感性C反應(yīng)蛋白(hs-CRP)水平。結(jié)果:兩組患者術(shù)后FFR、CFR比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05);高劑量組患者術(shù)后IMR顯著低于低劑量組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者術(shù)前CK、CK-MB和CRP水平比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05);術(shù)后,低劑量組患者CK-MB和CRP水平顯著升高,且顯著高于高劑量組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05);兩組患者術(shù)后CK水平比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者均未見明顯不良反應(yīng)發(fā)生。結(jié)論:在實(shí)施PCI術(shù)前,對(duì)NSTE-ACS患者預(yù)先使用高劑量阿托伐他汀(80→40 mg)可顯著改善患者微循環(huán)障礙,同時(shí)抑制炎癥反應(yīng)。
[Abstract]:Objective: to investigate the protective effect of different doses of Atto statins on (NSTEACS) patients with non-ST segment elevation acute coronary syndrome (NSTEACS) treated with percutaneous coronary intervention (PTCA). Methods: from January 2014 to April 2016, 81 patients with NSTE-ACS were randomly divided into high dose group (n = 40) and low dose group (n = 41). Patients in the high dose group were given Atto Vastatin calcium tablets at 12: 24 h before PCI, 80 mg, before operation, and then 40 mg; at 12: 24 h before PCI. The patients in the low dose group were given 10 mg. at 12: 24 h before PCI. The levels of creatine kinase (CK), creatine kinase isoenzyme (CK-MB) and high sensitivity C-reactive protein (hs-CRP) were compared between the two groups before and after operation. The coronary flow reserve fraction (CFR) and microcirculatory resistance index (IMR),) were compared between the two groups. Results: there was no significant difference in postoperative FFR,CFR between the two groups (P 0.05), but the postoperative IMR in the high dose group was significantly lower than that in the low dose group (P 0.05). There was no significant difference in the levels of CK,CK-MB and CRP between the two groups before operation (P 0.05). After operation, the levels of CK-MB and CRP in the low dose group were significantly higher than those in the high dose group (P 0.05). There was no significant difference in the level of CK between the two groups (P 0.05). No obvious adverse reactions were found in both groups. Conclusion: before PCI, the pre-treatment of high dose Atto varastatin (80 mg) can significantly improve the microcirculatory disturbance and inhibit the inflammatory response in patients with NSTE-ACS.
【作者單位】： 解放軍第464醫(yī)院心內(nèi)科;
【分類號(hào)】：R541.4

【相似文獻(xiàn)】

相關(guān)期刊論文 前3條

1 黃莉;;氨氯地平聯(lián)合阿托伐他汀治療高血壓合并冠心病的療效觀察[J];當(dāng)代醫(yī)學(xué);2014年12期

2 鄭瓊;張道進(jìn);楊陽;何北海;;急性冠狀動(dòng)脈綜合征患者早期應(yīng)用不同劑量的阿托伐他汀的有效性及安全性對(duì)比[J];四川醫(yī)學(xué);2014年04期

3 蘇淑紅;王志方;劉志強(qiáng);;經(jīng)皮冠狀動(dòng)脈介入治療術(shù)前強(qiáng)化他汀治療在非ST段抬高的急性冠脈綜合征患者中的安全性分析[J];臨床醫(yī)學(xué);2014年05期

相關(guān)博士學(xué)位論文 前1條

1 康琪;阿托伐他汀對(duì)急性心肌梗死大鼠心肌炎癥和纖維化反應(yīng)相關(guān)Notch1與TGF-β-Smad信號(hào)通路的作用以及對(duì)冠心病患者血漿炎性因子Galectin-3作用[D];天津醫(yī)科大學(xué);2017年

相關(guān)碩士學(xué)位論文 前3條

1 沈根;強(qiáng)化阿托伐他汀對(duì)造影劑急性腎損傷的預(yù)防作用[D];寧波大學(xué);2017年

2 李亞如;冠狀動(dòng)脈造影/經(jīng)皮冠狀動(dòng)脈介入術(shù)前強(qiáng)化阿托伐他汀預(yù)防對(duì)比劑腎病的meta分析[D];山西醫(yī)科大學(xué);2017年

3 魏倩倩;阿托伐他汀對(duì)心肌梗死合并糖尿病患者心率變異性的影響[D];青島大學(xué);2017年

，

本文編號(hào)：2526185