發(fā)布時(shí)間：2019-06-13 06:26

【摘要】：目的探討長(zhǎng)春瑞濱在輸液性靜脈炎小鼠模型建立中的作用及干預(yù)措施。方法選取健康成年小鼠,分別應(yīng)用不同給藥劑量、給藥濃度以及給藥速度,觀察靜脈炎發(fā)生情況,并應(yīng)用西咪替丁等不同的H2受體阻斷劑進(jìn)行干預(yù)。結(jié)果長(zhǎng)春瑞濱(VIN)給藥濃度以及注射速度不變的情況下,注射劑量越多,小鼠靜脈炎的發(fā)生率更高并且更加嚴(yán)重(P0.05);給藥濃度下降后增加了注射難度并提高了小鼠死亡率(P0.05);給藥速度越快,小鼠靜脈炎發(fā)生風(fēng)險(xiǎn)越高(P0.05);預(yù)先應(yīng)用西咪替丁可以顯著降低小鼠靜脈炎的發(fā)生率(P0.05)。結(jié)論制備動(dòng)物模型能夠?yàn)楦倪M(jìn)VIN用藥方法提供重要參考,并進(jìn)一步探索干預(yù)輸液性靜脈炎的藥物治療措施。
[Abstract]:Objective to investigate the role and intervention of vinorelabine in the establishment of infusion phlebitis in mice. Methods healthy adult mice were treated with different dosage, concentration and speed of administration, and the occurrence of phlebitis was observed, and cimetidine and other different H2 receptor blockers were used for intervention. Results the higher the dose of vinorelbin (VIN) was, the higher and more serious the incidence of phlebitis in mice was (P 0.05). The decrease of administration concentration increased the difficulty of injection and the mortality of mice (P 0.05). The faster the administration rate, the higher the risk of phlebitis in mice (P 0.05), the higher the risk of phlebitis in mice (P 0.05), the higher the risk of phlebitis in mice (P 0.05), and the higher the risk of phlebitis in mice (P 0.05). Cimetidine could significantly reduce the incidence of phlebitis in mice (P 0.05). Conclusion the establishment of animal model can provide an important reference for improving the drug use method of VIN and further explore the drug treatment measures for intervention of infusion phlebitis.
【作者單位】： 河南中醫(yī)藥大學(xué)第二附屬醫(yī)院(河南省中醫(yī)院);河南省胸科醫(yī)院;
【基金】：國(guó)家自然科學(xué)基金項(xiàng)目資助(No.81573919)
【分類號(hào)】：R-332;R543.6

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