發(fā)布時間：2019-03-23 16:08

【摘要】：正動脈粥樣硬化是一種以脂代謝紊亂和炎癥為主要表現(xiàn)的疾病,然而它也與內(nèi)皮細(xì)胞外基質(zhì)(extracellular matrix,ECM)的重塑和纖維連接蛋白(fibronectin)在層粘連蛋白(laminin)-膠原基底膜間的沉積密切相關(guān)。為了研究纖維連接蛋白如何調(diào)節(jié)動脈中的炎癥,Yun等將纖維連接蛋白受體整合素α5的胞質(zhì)尾區(qū)替換為膠原/層粘連蛋白受體整合素α2的胞質(zhì)尾區(qū)。這一
[Abstract]:Positive atherosclerosis is a disease characterized mainly by lipid metabolism disorder and inflammation. However, it is also associated with endothelial extracellular matrix (extracellular matrix,). The remodeling of ECM is closely related to the deposition of fibronectin (fibronectin) between laminin (laminin)-collagen basement membrane. In order to study how fibronectin regulates inflammation in arteries, Yun and others replaced the cytoplasmic tail region of fibronectin receptor integrin 偽 5 with that of collagen / laminin receptor integrin 偽 2. This one
【分類號】：R543.5
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本文編號：2446001