【摘要】：從動(dòng)態(tài)和穩(wěn)態(tài)兩個(gè)視角,研究直立傾斜(HUT)引起體位改變前后以及不同速度改變體位過(guò)程中RR間期(RRI)與收縮壓(SBP)間耦合性的變化。所用數(shù)據(jù)來(lái)自Phsio Net發(fā)布的體位變化所引起的生理響應(yīng)數(shù)據(jù)庫(kù)(PRCP),含有10位健康受試者(5男5女)在HUT過(guò)程中記錄的連續(xù)心電和動(dòng)脈血壓信號(hào)。慢速體位變化(ST)和快速體位(RT)變化分別為在50和2 s之間從水平仰臥升至75°傾斜。提取逐拍RRI和SBP數(shù)據(jù)后,運(yùn)用交叉時(shí)頻分析和信息分解方法,結(jié)合時(shí)域和短時(shí)分形指數(shù)(α1),進(jìn)行RRI和SBP時(shí)間序列的聯(lián)合分析。信息分解分析結(jié)果表明,所有的顯著差異集中在壓力反射導(dǎo)致心率變化的后向反饋回路(SBP→RRI),ST后心率的可預(yù)測(cè)性較平臥時(shí)顯著增高(0.416±0.067 vs 0.626±0.127),壓力反射支路的SBP-RRI耦合性升高。而在RRI→SBP方向,HUT對(duì)其幾乎沒(méi)有影響。ST和RT之前,所有的同類指標(biāo)相比均無(wú)顯著差異。ST和RT之后的穩(wěn)態(tài),雖然RRI無(wú)顯著差異,但較之ST之后,RT之后RRI的變異系數(shù)顯著升高(0.054±0.014 vs 0.074±0.027),α1顯著降低(1.45±0.25vs 1.28±0.27)。同時(shí),交叉時(shí)頻分析結(jié)果揭示了ST和RT過(guò)程中自主神經(jīng)不同的動(dòng)態(tài)反應(yīng)行為。研究證明了信息分解方法的有效性,可明確區(qū)分心率與血壓相互作用時(shí)的前向反饋和后向反饋的主導(dǎo)因果方向,而且可反映HUT前后信號(hào)可預(yù)測(cè)性的變化。
[Abstract]:In this paper, the coupling between RR interval (RRI) and systolic blood pressure (SBP) (SBP) induced by upright tilt (HUT) before and after posture change and different velocity changes were studied from two angles of view: dynamic and steady state. The data were obtained from the Phsio Net-published physiological response database (PRCP), which contained continuous ECG and arterial blood pressure signals recorded by 10 healthy subjects (5 males and 5 females) during HUT. Slow-velocity postural changes (ST) and rapid postural (RT) increased from horizontal supine to 75 擄tilt between 50 s and 2 s, respectively. After extracting the beat-by-beat RRI and SBP data, the time series of RRI and SBP are analyzed jointly by means of time-frequency analysis and information decomposition, combined with time-domain and short-time fractal index (偽 1). The results of information decomposition analysis showed that all significant differences were concentrated in the backward feedback loop (0.416 鹵0.067 vs 0.626 鹵0.127) in which baroreflex induced heart rate changes (0.416 鹵0.067 vs 0.626 鹵0.127) after SBP and RRI), ST. The SBP-RRI coupling of the baroreflex branch is increased. But in the direction of RRI and SBP, HUT had little effect on it. Before St and RT, there was no significant difference in all similar indexes. The steady state after St and RT, although there was no significant difference in RRI, was higher than that after ST. After RT, the coefficient of variation of RRI increased significantly (0.054 鹵0.014 vs 0.074 鹵0.027) and 偽 1 decreased significantly (1.45 鹵0.25vs 1.28 鹵0.27). At the same time, the results of cross-time-frequency analysis reveal the different dynamic response behavior of autonomic nerve in ST and RT. The results show that the information decomposition method is effective and can clearly distinguish the leading causal direction of forward feedback and backward feedback when heart rate and blood pressure interact with each other, and it can also reflect the change of signal predictability before and after HUT.
【作者單位】： 中國(guó)醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所北京協(xié)和醫(yī)學(xué)院基礎(chǔ)學(xué)院;中國(guó)生物醫(yī)學(xué)工程學(xué)會(huì);
【基金】：國(guó)家自然科學(xué)基金(81071225,81471746)
【分類號(hào)】：R540.4
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本文編號(hào)：2442337