【摘要】：目的探討腰臀比縱向軌跡與動(dòng)脈硬化的關(guān)聯(lián)。方法研究隊(duì)列由開灤卒中隊(duì)列、老年人群隊(duì)列、妊娠隊(duì)列和外周血管疾病篩查隊(duì)列組成,其中符合入選標(biāo)準(zhǔn)的研究對(duì)象共9080名。通過SAS Proc Traj程序確定觀察對(duì)象2006-2007、2008-2009、2010-2011年健康體檢的腰臀比縱向軌跡,生成4組不同的腰臀比軌跡組:低-中軌跡組、中-穩(wěn)定軌跡組、高-高軌跡組、高-中軌跡組,并于2010-2015年對(duì)觀察對(duì)象進(jìn)行了肱踝動(dòng)脈脈搏波傳導(dǎo)速度(baPWV)檢測(cè)。采用協(xié)方差分析校正了年齡、性別后不同腰臀比縱向軌跡分組baPWV的差異。采用多因素Logistic回歸模型分析腰臀比縱向軌跡與動(dòng)脈硬化的關(guān)聯(lián)。定義baPWV≥1400cm/s為動(dòng)脈硬化。結(jié)果與其他腰臀比軌跡組相比,高-高軌跡組的baPWV值[(1545.56±4.31)cm/s]、動(dòng)脈硬化人群比例(67.5%)均最高。低-中軌跡組、中-穩(wěn)定軌跡組、高-高軌跡組、高-中軌跡組動(dòng)脈硬化的發(fā)生率分別為:28.8%、50.0%、67.5%、55.4%。在多因素Logistic回歸分析中,校正了其他混雜因素后,與低-中軌跡組相比,中-穩(wěn)定軌跡組、高-高軌跡組、高-中軌跡組是動(dòng)脈硬化發(fā)生的危險(xiǎn)因素,對(duì)應(yīng)的OR值(95%CI)分別為1.42(1.15~1.76)、1.80(1.42~2.29)、1.63(1.11~2.38),均P0.05。此外,分別除外服用降壓藥、降糖藥、降脂藥人群后進(jìn)行了敏感性分析,結(jié)果與主要研究結(jié)果趨勢(shì)一致。結(jié)論腰臀比縱向軌跡水平升高是發(fā)生動(dòng)脈硬化的危險(xiǎn)因素。
[Abstract]:Objective to investigate the relationship between waist hip ratio longitudinal trajectory and arteriosclerosis. Methods the study cohort consisted of Kailuan stroke cohort, elderly population cohort, pregnancy cohort and peripheral vascular disease screening cohort. The longitudinal trajectory of waist-to-hip ratio was determined by SAS Proc Traj program in 2006 / 2007, 2008 / 2009, 2010-2011, and four different WHR trackgroups were generated: low-middle trackgroup, middle-stable trackgroup, high-high trackgroup, high-middle trackgroup, low-middle trackgroup, high-middle trackgroup. The pulse wave velocity (baPWV) of brachial-malleolar artery was measured from 2010 to 2015. Covariance analysis was used to correct the difference of baPWV between different waist-hip ratio longitudinal trajectory groups after age and sex. Multi-factor Logistic regression model was used to analyze the relationship between waist-hip ratio longitudinal trajectory and arteriosclerosis. BaPWV 鈮，

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