【摘要】：目的:研究羅布麻茶水提物對自發(fā)性高血壓大鼠(Spontaneous hypertension rat,SHR)血壓的調(diào)節(jié)規(guī)律以及降壓時相的出現(xiàn)與其它生理指標(biāo)變化的關(guān)系。方法:以SHR為實驗動物,每天灌胃1次受試物,每周1次采用尾套法連續(xù)測試灌胃后8~10 h內(nèi)的收縮壓及心率,6周后測試降壓時相的體質(zhì)量、尿量及尿鈉、尿鉀的分泌以及血脂含量。結(jié)果:與陰性對照組相比,灌胃羅布麻茶水提物后SHR收縮壓(SBP)先升高后下降,這種現(xiàn)象在連續(xù)灌胃3周后明顯,而心率無顯著的規(guī)律性變化;穩(wěn)定的降壓時相(8 h左右)在連續(xù)灌胃3周后出現(xiàn),最大降幅達16 mm Hg;降壓時相SHR的體質(zhì)量及血脂無顯著變化(P≥0.05),尿量及尿鈉、尿鉀的分泌顯著增加(P0.05)。結(jié)論 :羅布麻茶水提物對SHR收縮壓具有先升高后下降的雙向調(diào)節(jié)作用,然而起效慢,降壓時相的出現(xiàn)可能與其利尿及利鈉、利鉀作用有關(guān)。
[Abstract]:Aim: to study the regulation of (Spontaneous hypertension rat,SHR blood pressure and the relationship between the appearance of hypotensive phase and the changes of other physiological indexes. Methods: the systolic blood pressure (SBP) and heart rate (HR) of SHR were measured once a day, once a week, and 6 weeks later, the volume of body mass, urine volume and urine sodium were measured. Urinary potassium secretion and blood lipid content. Results: compared with the negative control group, SHR systolic pressure (SBP) increased at first and then decreased after the tea extract of Apocynum gavicum. This phenomenon was obvious after 3 weeks of continuous gastric perfusion, but there was no significant regular change of heart rate. Stable hypotensive phase (about 8 h) appeared after 3 weeks of continuous gastric perfusion, with a maximum decrease of 16 mm Hg;. There was no significant change in body mass and blood lipid of SHR at hypotensive phase (P > 0. 05), but urine volume, urine sodium and urinary potassium secretion were significantly increased (P0.05). Conclusion: Apocynum tea extract has a bidirectional regulating effect on systolic blood pressure of SHR, but its effect is slow. The phase of depressor phase may be related to its diuretic, natriuretic and potassium effects.
【作者單位】： 中國農(nóng)業(yè)大學(xué)食品科學(xué)與營養(yǎng)工程學(xué)院;渤海大學(xué)食品科學(xué)與工程學(xué)院;食品營養(yǎng)與人類健康高精尖創(chuàng)新中心食品科學(xué)與營養(yǎng)工程學(xué)院中國農(nóng)業(yè)大學(xué);
【基金】：北京市科技計劃項目(D121100003112004;D121100003112001)
【分類號】：R544.1

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