【摘要】：隨著社會老齡化的加快,動脈粥樣硬化的發(fā)生率逐年升高。目前認(rèn)為動脈粥樣硬化的始動環(huán)節(jié)是血管內(nèi)皮損傷,而脂質(zhì)代謝異常是血管損傷的主要危險因素�，F(xiàn)研究發(fā)現(xiàn)一些非脂質(zhì)物質(zhì)在血管損傷機制中起著重要的作用,如高同型半胱氨酸、高血糖以及高尿酸等。這些非脂質(zhì)因素主要作用于血管內(nèi)皮細(xì)胞,通過干擾黏附分子的表達(dá)、改變內(nèi)皮細(xì)胞的病理生理狀態(tài),進(jìn)而導(dǎo)致血管內(nèi)皮的損傷,促進(jìn)動脈粥樣硬化病灶的形成。本文主要介紹非脂質(zhì)危險因素致內(nèi)皮損傷時細(xì)胞黏附分子的變化的一些作用機制,并介紹干預(yù)黏附分子表達(dá)的一些治療靶點,對治療動脈粥樣硬化所導(dǎo)致的冠心病、心肌梗塞等心血管疾病具有重要的臨床意義。
[Abstract]:With the aging of society, the incidence of atherosclerosis increases year by year. At present, it is believed that vascular endothelial injury is the initiation of atherosclerosis, and abnormal lipid metabolism is the main risk factor of vascular injury. Some non-lipid substances have been found to play an important role in vascular injury, such as homocysteine, hyperglycemia and hyperuric acid. These non-lipid factors mainly act on vascular endothelial cells. By interfering with the expression of adhesion molecules, the pathophysiological state of endothelial cells is changed, which leads to the injury of vascular endothelium and promotes the formation of atherosclerotic lesions. This paper mainly introduces the mechanism of cell adhesion molecule changes in endothelial injury induced by non-lipid risk factors, and some therapeutic targets for the treatment of coronary heart disease caused by atherosclerosis. Cardiovascular diseases such as myocardial infarction have important clinical significance.
【作者單位】： 濟(jì)南大學(xué)山東省醫(yī)學(xué)科學(xué)院醫(yī)學(xué)與生命科學(xué)學(xué)院;濟(jì)南大學(xué)山東省醫(yī)學(xué)科學(xué)院藥物研究所山東省罕少見病重點實驗室;
【基金】：山東省自主創(chuàng)新及成果轉(zhuǎn)化專項(201402103)
【分類號】：R543.5

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 朱頌;谷津生;;高同型半胱氨酸血癥致病研究[J];中國城鄉(xiāng)企業(yè)衛(wèi)生;2015年06期

2 劉婉君;王濤;王貝;劉心甜;賀行巍;劉玉建;李柱錫;譚蓉;曾和松;;CYP2C8-derived Epoxyeicosatrienoic Acids Decrease Oxidative Stress-induced Endothelial Apoptosis in Development of Atherosclerosis:Role of Nrf2 Activation[J];Journal of Huazhong University of Science and Technology(Medical Sciences);2015年05期

3 Annette Graham;Anne-Marie Allen;;Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responses[J];World Journal of Cardiology;2015年05期

4 Darlene Vigil;Kavitha Ganta;Yijuan Sun;RichardⅠDorin;Antonios H Tzamaloukas;Karen S Servilla;;Prolonged hypernatremia triggered by hyperglycemic hyperosmolar state with coma: A case report[J];World Journal of Nephrology;2015年02期

5 Barbara RUSZKOWSKA-CIASTEK;Alina SOKUP;Tomasz WERNIK;Zofia RUPRECHT;Barbara GóRALCZYK;Krzysztof GóRALCZYK;Grazyna GADOMSKA;Danuta RO;;未受控制的高血糖對2型糖尿病患者粘附分子的影響（英文）[J];Journal of Zhejiang University-Science B(Biomedicine & Biotechnology);2015年05期

6 喬云;張鵬舉;鹿曉婷;孫巍巍;劉桂林;任敏;閆磊;張繼東;;Panax Notoginseng Saponins Inhibits Atherosclerotic Plaque Angiogenesis by Down-Regulating Vascular Endothelial Growth Factor and Nicotinamide Adenine Dinucleotide Phosphate Oxidase Subunit 4 Expression[J];Chinese Journal of Integrative Medicine;2015年04期

7 朱琳;王彥軍;俞天虹;羅光華;魏江;于洋;賈方;孫建輝;;紅景天苷通過抑制內(nèi)質(zhì)網(wǎng)應(yīng)激減少高同型半胱氨酸誘導(dǎo)的人臍靜脈內(nèi)皮細(xì)胞損傷[J];中國動脈硬化雜志;2015年01期

8 Hui-yong PENG;Chang-feng MAN;Juan XU;Yu FAN;;血漿同型半胱氨酸水平升高與心血管疾病及各種死亡風(fēng)險因子的meta分析(英文)[J];Journal of Zhejiang University-Science B(Biomedicine & Biotechnology);2015年01期

9 Xiang Xu;Hui Chen;Bing-Yu Ling;Lan Xu;Hong Cao;Yu-Qiu Zhang;;Extracellular signal-regulated protein kinase activation in spinal cord contributes to pain hypersensitivity in a mouse model of type 2 diabetes[J];Neuroscience Bulletin;2014年01期

10 何玉萍;江ng;何玉珊;許翌嘉;;氧化低密度脂蛋白對血管內(nèi)皮細(xì)胞黏附分子表達(dá)的影響[J];中西醫(yī)結(jié)合心腦血管病雜志;2013年05期

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