【摘要】：心臟驟停后綜合征(post-cardiac arrest syndrome,PCAS),過去稱為“復蘇后綜合征”,是臨床上的急危重癥。它是心臟驟停(CA)患者經(jīng)過心肺復蘇恢復自主循環(huán)后(resumption of spontaneous circulation,ROSC)所產(chǎn)生的急性缺血-再灌注損傷及一系列復雜的病理生理改變。若不及時救治,臨床病死率很高。造成這種低存活率的原因極其復雜,為了提高存活率,需及早治療,目前臨床上的治療措施主要有心電血氧重癥監(jiān)護、早期血流動力學優(yōu)化、氧合與機械通氣、亞低溫治療等,其中亞低溫治療是目前唯一證實對腦保護有效的措施,是當前研究熱點,但仍存在不少爭議。因PCAS的高死亡率和神經(jīng)功能致殘率,臨床上需通過某些相關因素及評分方法對PCAS患者的預后做出判斷評估以便指導臨床工作中的診治,同時減少不必要的治療為患者家庭所帶來的巨大的負擔。本文通過文獻回顧,就心臟驟停后綜合征的臨床治療進展及預后相關因素做一綜述。
[Abstract]:Cardiac arrest syndrome (post-cardiac arrest syndrome,PCAS), formerly known as postresuscitation syndrome, is a clinical emergency. It is an acute ischemia-reperfusion injury and a series of complex pathophysiological changes in (CA) patients after cardiopulmonary resuscitation (CPR) and spontaneous circulation (resumption of spontaneous circulation,ROSC). If not timely treatment, the clinical mortality is very high. The reasons for this low survival rate are extremely complicated. In order to improve the survival rate, early treatment is required. At present, the main clinical treatment measures are ECG intensive care, early hemodynamics optimization, oxygenation and mechanical ventilation, mild hypothermia treatment, etc. Mild hypothermia therapy is the only effective measure to protect the brain. Because of the high mortality rate and neurological disability rate of PCAS, it is necessary to evaluate the prognosis of PCAS patients by some relevant factors and scoring methods in order to guide the diagnosis and treatment in clinical work. At the same time, reduce the unnecessary treatment on the patient's family to bring a huge burden. This article reviews the clinical treatment and prognostic factors of post-cardiac arrest syndrome.
【學位授予單位】：蚌埠醫(yī)學院
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R541.78

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本文編號：2358575