【摘要】：目的:分析硼替佐米致心力衰竭的發(fā)生規(guī)律及特點(diǎn),為安全用藥提供參考。方法:檢索國內(nèi)外硼替佐米致心力衰竭個(gè)案報(bào)道文獻(xiàn)進(jìn)行分析。結(jié)果:共檢索到硼替佐米致心力衰竭個(gè)案報(bào)道11篇,涉及14例患者,男性8例,女性6例,年齡≥60歲的老年患者7例,有心血管疾病基礎(chǔ)疾病及接受過蒽環(huán)類藥物治療分別有5例,有7例在第4次化療周期后發(fā)生心力衰竭。硼替佐米致心力衰竭臨床表現(xiàn)主要為呼吸困難,心胸比率增大,左、右室內(nèi)徑增加,LVEF下降,BNP增高。結(jié)論:有心血管疾病基礎(chǔ)疾病及蒽環(huán)類藥物使用史可能更易發(fā)生心力衰竭,應(yīng)加強(qiáng)硼替佐米致心力衰竭監(jiān)測(cè),重點(diǎn)防治,減少其發(fā)生。
[Abstract]:Objective: to analyze the occurrence and characteristics of bortezomib induced heart failure in order to provide reference for safe drug use. Methods: to search the literature of bortezomib induced heart failure at home and abroad. Results: a total of 11 cases of bortezomib induced heart failure were reported, involving 14 patients, 8 males, 6 females, 7 elderly patients aged more than 60 years. There were 5 cases of cardiovascular disease and 5 cases of anthracycline treatment, and 7 cases developed heart failure after the fourth chemotherapy cycle. The clinical manifestations of bortezomib in heart failure were dyspnea, cardiothoracic ratio, left and right ventricular diameter, LVEF and BNP. Conclusion: heart failure may be more likely to occur in patients with underlying cardiovascular diseases and anthracycline use. The monitoring of heart failure caused by bortezomib should be strengthened to focus on prevention and treatment and to reduce the occurrence of heart failure.
【作者單位】： 安徽省蚌埠市第三人民醫(yī)院藥學(xué)部;
【分類號(hào)】：R541.6

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