【摘要】：目的探討血管生成素樣蛋白2(Angptl2)在下肢動(dòng)脈粥樣硬化閉塞癥患者血漿中的水平,以及其在下肢動(dòng)脈粥樣硬化閉塞癥不同階段的變化及其意義。方法分析75例下肢動(dòng)脈粥樣硬化閉塞癥患者(病例組)及65例健康體檢者(對(duì)照組)血漿Angptl2水平。常規(guī)檢測(cè)血生化指標(biāo)及超敏C反應(yīng)蛋白,采用酶聯(lián)免疫分析法測(cè)定血漿Angptl2、脂聯(lián)素水平。結(jié)果下肢動(dòng)脈粥樣硬化閉塞癥患者血漿Angptl2水平較健康對(duì)照顯著升高[(13.55±9.17)μg/L比(9.04±4.79)μg/L,P=0.010]。糖尿病人群中,下肢動(dòng)脈粥樣硬化閉塞癥患者的血漿Angptl2水平(18.67±9.84)μg/L較對(duì)照組(13.01±3.47)μg/L升高(P=0.021)。在重癥下肢缺血組Angptl2水平較間歇性跛行組更高[(17.01±10.20)μg/L比(10.53±6.97)μg/L,P=0.003]。Angptl213.67μg/L診斷效果最好,敏感性為60.34%,特異性為81.25%。在病例組中,血漿Angptl2水平與踝-肱指數(shù)呈負(fù)相關(guān)(斯皮爾曼相關(guān)系數(shù)=-0.244,P=0.035)。結(jié)論下肢動(dòng)脈粥樣硬化閉塞癥患者的血漿Angptl2水平升高。當(dāng)疾病進(jìn)展為重癥下肢缺血時(shí),Angptl2水平的升高更為明顯,可以作為判斷疾病進(jìn)展程度的潛在生物學(xué)標(biāo)志物。
[Abstract]:Objective to investigate the level of angiopoietin-like protein-2 (Angptl2) in plasma of patients with lower extremity atherosclerosis obliteration and its significance in different stages of lower extremity atherosclerosis obliteration. Methods Plasma Angptl2 levels in 75 patients with lower extremity atherosclerosis obliterans (case group) and 65 healthy controls (control group) were analyzed. Blood biochemical indexes and hypersensitive C reactive protein were detected by routine method. Plasma Angptl2, adiponectin levels were measured by enzyme linked immunosorbent assay (Elisa). Results Plasma Angptl2 levels in patients with lower extremity atherosclerosis obliterans were significantly higher than those in healthy controls [(13.55 鹵9.17) 渭 g / L vs (9.04 鹵4.79) 渭 g / L]. The plasma Angptl2 level in patients with lower extremity atherosclerosis obliterans was (18.67 鹵9.84) 渭 g / L higher than that in the control group (13.01 鹵3.47) 渭 g / L (P = 0.021). The level of Angptl2 in severe lower extremity ischemia group was higher than that in intermittent claudication group [(17.01 鹵10.20) 渭 g / L vs (10.53 鹵6.97) 渭 g / L]. Angptl213.67 渭 g / L was the best in diagnosis, and the sensitivity was 60.34. The specificity was 81.25. In the case group, plasma Angptl2 level was negatively correlated with malleolus brachial index (Spelman correlation coefficient = -0.244 P0. 035). Conclusion Plasma Angptl2 levels in patients with lower extremity atherosclerosis obliterans are elevated. When the disease progresses to severe lower extremity ischemia, the increase of Angptl2 level is more obvious, and it can be used as a potential biomarker to judge the degree of disease progression.
【作者單位】： 中國(guó)醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院北京協(xié)和醫(yī)院血管外科;內(nèi)蒙古自治區(qū)人民醫(yī)院血管外科;首都醫(yī)科大學(xué)附屬北京朝陽(yáng)醫(yī)院血管外科;首都醫(yī)科大學(xué)生理學(xué)與病理生理學(xué)系;大連醫(yī)科大學(xué)附屬第一醫(yī)院心血管病研究所心內(nèi)科;大連醫(yī)科大學(xué)公共衛(wèi)生學(xué)院慢性非傳染性疾病預(yù)防控制中心;
【基金】：國(guó)家自然科學(xué)基金(81270390)~~
【分類號(hào)】：R543.5

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 劉玉清;;動(dòng)脈粥樣硬化/粥樣硬化血栓癥:影像學(xué)和臨床意義[J];中國(guó)循環(huán)雜志;2007年04期

2 余國(guó)膺;活化血小板在動(dòng)脈粥樣硬化形成中起一定作用[J];中國(guó)慢性病預(yù)防與控制;2003年02期

3 馬向波;王彥富;李清賢;;糖化低密度脂蛋白水平與冠脈粥樣硬化程度的關(guān)系[J];山東大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2013年12期

4 李偉其;曾龍宏;莫玉前;;蛋白轉(zhuǎn)化酶枯草溶菌素9檢測(cè)對(duì)診斷冠脈粥樣硬化的臨床意義[J];中國(guó)實(shí)用醫(yī)藥;2014年13期

5 王敏,李長(zhǎng)玉;老年人下肢動(dòng)脈粥樣硬化的危險(xiǎn)因素[J];中國(guó)心血管雜志;2004年05期

6 袁志敏;;抑郁癥狀與老年人頸總動(dòng)脈粥樣硬化間關(guān)系[J];國(guó)外醫(yī)學(xué)(老年醫(yī)學(xué)分冊(cè));2008年06期

7 董朱光;粥樣硬化切除和球囊擴(kuò)張去除血管支撐物內(nèi)內(nèi)膜增生[J];國(guó)外醫(yī)學(xué)(臨床放射學(xué)分冊(cè));1991年03期

8 晏沐陽(yáng),雷小瑩,馬兆龍;主——髂動(dòng)脈粥樣硬化的血管內(nèi)成形術(shù)的進(jìn)展[J];局解手術(shù)學(xué)雜志;1998年01期

9 陳美娟;李亮;李華;劉劍;顧立;肖順漢;黃愛萍;吳章懷;;“國(guó)窖·1573”對(duì)兔動(dòng)脈粥樣硬化的影響[J];釀酒;2007年01期

10 蘇建春;于云華;塔依爾江;李葆華;李潔;;淺談中西醫(yī)結(jié)合防治下肢動(dòng)脈粥樣硬化的優(yōu)勢(shì)[J];中醫(yī)雜志;2009年09期

相關(guān)會(huì)議論文 前10條

1 許鵬程;許洪陶;馬澗泉;龔蘭真;;膳食因素對(duì)于以大米——黃豆為主膳的大白鼠血清膽固醇及動(dòng)，

本文編號(hào)：2297301