【摘要】：目的探討冠心病合并糖耐量減低患者脂蛋白(a)[Lp(a)]、超敏C反應蛋白(hs CRP)和穩(wěn)態(tài)模型的胰島素抵抗指數(shù)(HOMA-IR)的變化及其相互間的關(guān)系和意義。方法測定40例冠心病合并糖耐量減低患者(CHD+IGT組)和40例冠心病糖耐量正�；颊�(CHD組)及30例體檢健康者(正常對照組)的Lp(a)、hs CRP等指標,用酶聯(lián)免疫吸附測定法(ELISA)測定血清中Lp(a)、hs CRP;同時檢測3組的空腹血糖、空腹胰島素并計算HOMA-IR,穩(wěn)態(tài)模型評估胰島素抵抗指數(shù)(HOMA-IR)胰島素抵抗程度采用穩(wěn)態(tài)模式HOMA-IR進行評估。分析各組病例中Lp(a)、hs CRP指標的變化及其與HOMA-IR的關(guān)系。應用SPSS17.0統(tǒng)計學軟件包進行統(tǒng)計分析,正態(tài)分布參數(shù)以平均數(shù)±標準差,非正態(tài)分布參數(shù)經(jīng)對數(shù)轉(zhuǎn)換,組間比較采用t檢驗,多組間比較采用方差分析;Lp(a)及hs CRP與HOMA-IR有關(guān)的因素作Pearson相關(guān)性分析。結(jié)果CHD+IGT組與CHD組及正常對照組比較Lp(a)、hs CRP、HOMA-IR均顯著升高,差異有統(tǒng)計學意義(P0.05),CHD組與正常對照組比較Lp(a)、hs CRP、HOMA-IR顯著升高,差異有統(tǒng)計學意義(P0.05)。Lp(a)、hs CRP均與HOMA-IR呈正相關(guān)。結(jié)論冠心病合并糖耐量減低患者Lp(a)、hs CRP表達及HOMA-IR明顯升高,Lp(a)、hs CRP與HOMA-IR成正相關(guān),Lp(a)、hs CRP及胰島素抵抗共同參與了CHD合并糖尿量減低,Lp(a)、hs CRP及HOMA-IR在CHD合并糖耐量減低患者病情評估與治療監(jiān)測等方面有重要的參考意義。
[Abstract]:Objective to investigate the changes of lipoprotein (a) [Lp (a)], hypersensitive C-reactive protein (hs CRP) and insulin resistance index (HOMA-IR) in patients with coronary heart disease complicated with impaired glucose tolerance. Methods Lp (a), hs CRP was measured in 40 patients with coronary heart disease with impaired glucose tolerance (CHD IGT group), 40 patients with normal glucose tolerance (CHD group) and 30 healthy subjects (normal control group). Fasting blood glucose, fasting insulin and insulin resistance index (HOMA-IR) of the three groups were measured by enzyme linked immunosorbent assay (ELISA). Fasting insulin and insulin resistance index (HOMA-IR) were evaluated by steady-state HOMA-IR. The changes of Lp (a), hs CRP and their relationship with HOMA-IR were analyzed. The statistical analysis was carried out by SPSS17.0 statistical software package. The parameters of normal distribution were mean 鹵standard deviation, the parameters of non-normal distribution were transformed by logarithm, and the t test was used to compare the parameters between groups. The analysis of variance (; Lp (a) and the factors related to hs CRP and HOMA-IR were used to analyze the correlation of Pearson. Results Lp (a), hs CRP,HOMA-IR in CHD IGT group was significantly higher than that in CHD group and normal control group, and the difference was statistically significant (P0.05 between), CHD group and normal control group), and the difference was statistically significant (P0.05). Lp (a), hs CRP was positively correlated with HOMA-IR). Conclusion the expression of Lp (a), hs CRP and the increase of HOMA-IR in patients with coronary heart disease complicated with impaired glucose tolerance are positively correlated with, Lp (a), hs CRP and insulin resistance, which may be involved in, Lp (a), hs CRP and HOMA-IR of CHD with impaired glucose and urine volume in CHD patients with impaired glucose tolerance. Evaluation and treatment monitoring have important reference significance.
【學位授予單位】：青島大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R541.4
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本文編號：2289351